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The effect of breed on ivermectin residues in the edible tissues of cattle and the estimated withdrawal period.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Research Centre for Veterinary Toxicology (CEPTOX) - Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.
This study analyzed the residue depletion kinetics of ivermectin (IVM) in Nelore and crossbred (Nelore x Angus) cattle aiming to compare the profiles between the breeds and evaluate the residue levels at the injection site. IVM 1%, at a dose of 0.2 mg/kg, was administered the subcutaneous route, and tissue samples were collected on different days post administration for analysis by LC-MS/MS.
View Article and Find Full Text PDFPharmacokinetics, optimal dosages and withdrawal time of amoxicillin in Nile tilapia () reared at 25 and 30 °C.
Vet Q
December 2024
Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
Knowledge of amoxicillin (AMX) pharmacokinetics (PK) and tissue residues in fish, which is necessary for prudent drug use, remains limited. The study aimed to explore the PK characteristics of AMX in Nile tilapia () reared at 25 and 30 °C as well as to determine optimal dosages and drug withdrawal time (WDT). In the PK investigation, the fish received a single dose of 40 mg/kg AMX oral gavage, and the optimal dosage was determined by the pharmacokinetic-pharmacodynamic approach.
View Article and Find Full Text PDFEstimation of withdrawal interval recommendations following administration of fenbendazole medicated feed to ring-necked pheasants ().
Front Vet Sci
July 2024
Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Article Synopsis
- The study investigates the safe withdrawal interval (WDI) for fenbendazole in pheasants, as its use is considered extra-label in the U.S.
- Pheasants received fenbendazole medicated feed for 7 days, with tissue samples analyzed to determine drug metabolism and residue levels.
- Results indicate a maximum WDI of 153 hours for certain muscles, establishing fenbendazole sulfoxide as a key residue marker in pheasant liver, supporting safe food practices.
Pharmacokinetics of long-acting cephapirin and cloxacillin after intramammary administration in dairy goats.
J Vet Pharmacol Ther
September 2024
Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa, USA.
Determining the pharmacokinetics of intramammary antimicrobials in goats can assist in predicting appropriate meat and milk withdrawal intervals for drugs that are effective at treating subclinical mastitis due to non-aureus Staphylococci during the dry period. Twenty-four healthy, lactating does were enrolled in this study. Half were administered 300 mg of cephapirin benzathine (ToMORROW, Boehringer Ingelheim Vetmedica, Duluth, GA) via intramammary infusion into each half of the udder.
View Article and Find Full Text PDFDepletion kinetics of semicarbazide in giant river prawn (Macrobrachium rosenbergii) following nitrofurazone oral administration and its occurrence in an aquaculture farm.
Environ Toxicol Pharmacol
April 2024
Department of Fishery Biology, Faculty of Fisheries, Kasetsart University, Bangkok, Thailand. Electronic address:
Semicarbazide (SEM), a marker residue used to monitor the use of prohibited drug nitrofurazone (NFZ), is commonly found in wild crustaceans, implying the natural origin. However, the difference between endogenous and exogenous SEM has rarely been investigated. So, tissue-bound SEM was determined in samples collected from giant river prawns cultured in an aquaculture farm and in samples from an experiment where giant river prawns were fed twice a day with NFZ at 30 mg/kg for 5 days.
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