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Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Lancet
June 2024
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address:
Article Synopsis
- A clinical trial called RADICALS-HD studied the effects of adding short-course androgen deprivation therapy (ADT) to postoperative radiotherapy in patients with localized prostate cancer after surgery.
- It involved 1480 patients, examining how ADT impacts metastasis-free survival compared to radiotherapy alone, and measured outcomes like distant metastasis and overall survival.
- The trial aimed to see if combining ADT with radiotherapy could improve the 10-year metastasis-free survival rate, potentially increasing it from 80% to 86%.
Intraoperative unfractionated heparin before femoral component cementation should be avoided in femoral neck fracture treated with hybrid total hip arthroplasty.
Eur J Orthop Surg Traumatol
August 2023
Sir John Charnley' Hip Surgery Unit, Institute of Orthopaedics 'Carlos E. Ottolenghi', Italian Hospital of Buenos Aires, 4190 Peron St, C1199ABH, Buenos Aires, Argentina.
Purpose: To compare the incidence of perioperative thromboembolic events in femoral neck fracture (FNF) patients treated with hybrid total hip arthroplasty (THA) with intraoperative unfractionated heparin (UFH) versus a control group without intraoperative UFH before femoral component cementation.
Methods: We compared 139 cases without UFH (group A) versus 134 who received 10 UI/kg UFH (group B). Indication of UFH before cementation depended on the preferences of the anaesthesiologists in each case.
Early Results of Total Cementless Hip Joint Arthroplasty with the Anatomical Stem.
Ortop Traumatol Rehabil
June 2021
Klinika Ortopedii i Ortopedii Dziecięcej Uniwersytetu Medycznego w Łodzi, Łódź, Polska / Department of Orthopaedics and Paediatric Orthopaedics, Medical University of Lodz, Poland.
Background: The aim of this study is to present the early results of hip joint arthroplasty with the EXCEPTION anatomical stem (BIOMET).
Materials And Methods: The study enrolled 173 patients (110 women and 63 men) who underwent a total of 190 hip joint arthroplasties with the EXCEPTION anatomical stem. The mean age of the patients at surgery was 58.
Photothermal release and recovery of mesenchymal stem cells from substrates functionalized with gold nanorods.
Acta Biomater
July 2021
ARC Training Centre in Biodevices, Faculty of Science Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122 Australia; Department of Chemistry and Physics, La Trobe Insitute for Molecular Science, La Trobe University, Bundoora 3083, Australia. Electronic address:
Mesenchymal stem cell therapies show great promise in regenerative medicine. However, to generate clinically relevant numbers of these stem cells, significant in vitro expansion of the cells is required before transplantation into the affected wound or defect. The current gold standard protocol for recovering in vitro cultured cells involves treatment with enzymes such as trypsin which can affect the cell phenotype and ability to interact with the environment.
View Article and Find Full Text PDFDiagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study.
HPB (Oxford)
August 2021
Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
Background: Pancreatic duct disruption or disconnection is a potentially severe complication of necrotizing pancreatitis. With no existing treatment guidelines, it is unclear whether there is any consensus among experts in clinical practice. We evaluated current expert opinion regarding the diagnosis and treatment of pancreatic duct disruption and disconnection in an international case vignette study.
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