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Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering.
Front Bioeng Biotechnol
January 2025
Department of Agricultural and Environmental Sciences - Production, Landscape, Agroenergy, Università degli Studi di Milano, Milan, Italy.
Accelerating the genetic selection to obtain animals more resilient to climate changes, and with a lower environmental impact, would greatly benefit by a substantial shortening of the generation interval. One way to achieve this goal is to generate male gametes directly from embryos. However, spermatogenesis is a complex biological process that, at present, can be partially reproduced only in the mouse.
View Article and Find Full Text PDFDapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
PLoS One
January 2025
Hebei General Hospital, Shijiazhuang City, Hebei Province, P.R. China.
Objective: To study the effect of Dapagliflozin on ferroptosis in rabbits with chronic heart failure and to reveal its possible mechanism.
Methods: Nine healthy adult male New Zealand white rabbits were randomly divided into Sham group (only thorax opening was performed in Sham group, no ascending aorta circumferential ligation was performed), Heart failure group (HF group, ascending aorta circumferential ligation was performed in HF group to establish the animal model of heart failure), and Dapagliflozin group (DAPA group, after the rabbit chronic heart failure model was successfully made in DAPA group). Dapagliflozin was given by force-feeding method.
High-Conductivity, Self-Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human-Machine Interactions Under Extreme Cold Conditions.
Adv Sci (Weinh)
January 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human-machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self-healing, and strong adhesion, particularly under extreme low-temperature conditions. In this study, a novel ICH composed of sulfobetaine methacrylate, methacrylic acid, TEMPO-oxidized cellulose nanofibers, sodium alginate, and lithium chloride is presented.
View Article and Find Full Text PDFDesign for Telecom-Wavelength Quantum Emitters in Silicon Based on Alkali-Metal-Saturated Vacancy Complexes.
ACS Nano
January 2025
Division of Physical Sciences, College of Letters and Science, University of California Los Angeles, Los Angeles, California 90095, United States.
Defect emitters in silicon are promising contenders as building blocks of solid-state quantum repeaters and sensor networks. Here, we investigate a family of possible isoelectronic emitter defect complexes from a design standpoint. We show that the identification of key physical effects on quantum defect state localization can guide the search for telecom-wavelength emitters.
View Article and Find Full Text PDFMyeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis with silicosis, alveolar hemorrhage, and rapidly progressive glomerulonephritis: a case report.
AME Case Rep
October 2024
Center for Asbestos-Related Diseases, Toyama Rosai Hospital, Toyama, Japan.
Background: The underlying pathophysiology of some occupational diseases such as silicosis involves autoantibodies. An autoantibody, antineutrophil cytoplasmic antibody (ANCA), has been recently reported and is known to be elevated in diseases such as vasculitis; therefore, the disease is currently known as ANCA-associated vasculitis. The risk of ANCA-associated vasculitis is known to be 25 times higher in patients with silicosis than in those without any occupational disease.
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