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Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis.
Neurology
April 2025
Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom.
Background And Objectives: The diagnosis of multiple sclerosis (MS) requires evidence of both dissemination in space (DIS) and time (DIT); oligoclonal bands (OCBs) in the CSF can substitute for DIT on MRI. We investigated whether DIT (or positive CSF) is necessary to make a diagnosis of MS in patients who fulfil a high number of DIS criteria.
Methods: We prospectively recruited patients with a first demyelinating event evaluated with brain and spinal cord MRI within 3 months of onset.
Parent and pediatric nurse practitioner views on integrating the digital TELL tool intervention into clinical practice.
J Pediatr Nurs
February 2025
Department of Human Development Nursing Science, College of Nursing, University of Illinois Chicago, 845 S. Damen Ave., MC 802, Chicago, IL 60612, USA. Electronic address:
Purpose: To understand the views of parent participants in our larger pilot randomized controlled trial (RCT) about the Tool to Empower Parental TeLling and TaLking or the TELL Tool, a digital, psychoeducational and decision-support intervention; and to foster understanding about how pediatric nurse practitioners (PNPs) viewed integrating the TELL Tool into pediatric clinical settings.
Design And Methods: In this qualitative descriptive study, a purposive sample of 10 parents and 10 PNPs completed in-depth, semi-structured interviews by Zoom. The recordings were auto transcribed, checked for accuracy, and analyzed for themes.
Attitudes of Neurologists Toward Serum Neurofilament Light-Chain Testing in the Management of Relapsing-Remitting Multiple Sclerosis with Cognitive Impairment.
J Pers Med
February 2025
Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada.
Cognitive impairment has an impact upon the function and quality of life of patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression and are also associated with impaired cognitive performance. This study aimed to assess the attitudes of neurologists toward sNfL testing as regards making therapeutic decisions in clinically and radiologically stable patients experiencing cognitive decline.
View Article and Find Full Text PDFThe bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis.
iScience
February 2025
Department of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.
Brain metastases (BrMs) are the most common brain tumors in patients and are associated with poor prognosis. Investigating the systemic and environmental factors regulating BrM biology represents an important strategy to develop effective treatments. Toward this goal, we explored the contribution of the gut microbiome to BrM development by using breast-BrM models under germ-free conditions or antibiotic treatment.
View Article and Find Full Text PDFAltered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia.
EBioMedicine
February 2025
Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Cognitive Neuroscience Centre (CNC), Universidad de San Andres, Buenos Aires, Argentina; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), California, USA; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. Electronic address:
Background: Dysfunctional allostatic-interoception, altered processing of bodily signals in response to environmental demands, occurs in behavioural-variant frontotemporal dementia (bvFTD) patients. Previous research has not investigated the dynamic nature of interoception using methods like intrinsic neural timescales. We hypothesised that longer intrinsic neural timescales of interoception would occur in bvFTD patients, evidencing dysfunctional allostatic-interoception.
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