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[Severe digoxin poisoning a case study].
Przegl Lek
March 2012
Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej.
Article Synopsis
- * Digoxin helps strengthen heart contractions but can cause dangerous side effects, particularly when blood levels exceed 2.8 ng/ml, leading to symptoms like nausea, arrhythmias, and conduction disturbances.
- * A 45-year-old woman deliberately took a high dose of digoxin, resulting in severe poisoning despite immediate medical intervention, requiring symptomatic treatment due to the lack of specific antidotes.
[The inotropic and bathmotropic effects of beta stimulation: a study comparing dobutamine and dopamine on the guinea-pig papillary muscle in isotonic contraction].
Cardiologia
September 1992
II Cattedra di Cardiologia, Istituto di Chirurgia del Cuore e Grossi Vasi, Università degli Studi La Sapienza, Roma.
The study was aimed at comparing the effects of dobutamine (dob) and dopamine (dop) on isotonic contraction and rhythmicity of isolated guinea-pig papillary muscles (in oxygenated Tyrode at 37 degrees C), by taking into account: 1) the rate of stimulation (50% above the diastolic threshold) at 5 fixed periods: (RR: 1600, 1200, 1000, 800 and 400 ms); 2) 7 log concentrations (logC) of the index amine (from 10(-9) to 10(-3) M). To this end, a dose-relation protocol which explored the effects of all 5 RR and 7 logC was designed and 15 adult female Guinea-pigs (250 to 350 g) were randomized to either the dob (n = 8) or the dop (n = 7) arm. This enabled a total of 525 sets of data to be analyzed: in 38 sets (7.
View Article and Find Full Text PDFWhat role do alpha- and beta-adrenoceptors play in the regulation of the heart?
Eur Heart J
January 1983
Ahlquist described the existence of beta-adrenoceptors as structures mediating the positive effects of sympathetic nerve stimulation in the heart. Recently, the role of alpha-adrenoceptors has also been investigated by both biological and radioligand binding studies. The presence of alpha-adrenoceptors has now been demonstrated in the hearts of various mammalian species including man.
View Article and Find Full Text PDFThe object of this study is to examine the properties of dopamine at the hemodynamic and renal level in 16 patients with decompensated chronic cardiopathies or very serious cardiogenic shock due to myocardial infarction. The results show an increase in the cardiac index in 75 p. 100 of the cases with a favourable diminution of the arterio-venous difference in O2 and of the pulmonary arterial resistances.
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