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AMP dependent protein kinase regulates endothelial heparan sulfate expression in response to an inflammatory stimulus under arterial shear stress.
Biochem Biophys Res Commun
November 2024
Department of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address:
Heparan sulfate (HS) is the most abundant glycosaminoglycan on the vascular endothelium and can regulate endothelial cell morphology and function in response to mechanical stimuli. This study investigated endothelial HS response to an inflammatory stimulus under static and arterial shear stress conditions. Human aortic endothelial cells (HAECs) under static conditions expressed significantly higher HS when treated with an inflammatory stimulus compared to untreated controls.
View Article and Find Full Text PDFUtility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause.
Hamostaseologie
October 2024
Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion after exhaustive evaluation of plasmatic coagulation and platelet function. This review explores the utility of global hemostatic assays as confirmatory tests and in elucidating the pathophysiology of BDUC. Unlike traditional hemostatic tests that focus on coagulation factors, global assays are conducted both in plasma and also whole blood.
View Article and Find Full Text PDFUnfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity.
bioRxiv
February 2024
Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA.
Protein S (PS), the critical plasma cofactor for the anticoagulants tissue factor (TF) pathway inhibitor (TFPI) and activated protein C (APC), circulates in two functionally distinct pools: free (anticoagulant) or bound to complement component 4b-binding protein (C4BP) (anti-inflammatory). Acquired free PS deficiency is detected in several viral infections, but its cause is unclear. Here, we identified a shear-dependent interaction between PS and von Willebrand Factor (VWF) by mass spectrometry.
View Article and Find Full Text PDFUniversal Biomaterial-on-Chip: a versatile platform for evaluating cellular responses on diverse biomaterial substrates.
J Mater Sci Mater Med
January 2024
Division of Biomedical Engineering, Department of Materials Science and Engineering, Science for Life Laboratory, Uppsala University, 751 22, Uppsala, Sweden.
Microfluidics has emerged as a promising approach for assessing cellular behavior in vitro, providing more physiologically relevant cell culture environments with dynamic flow and shear stresses. This study introduces the Universal Biomaterial-on-Chip (UBoC) device, which enables the evaluation of cell response on diverse biomaterial substrates in a 3D-printed microfluidic device. The UBoC platform offers mechanical stimulation of the cells and monitoring of their response on diverse biomaterials, enabling qualitative and quantitative in vitro analysis both on- and off-chip.
View Article and Find Full Text PDFColloidal Deposition by Polymer-Surfactant Complexes with Dilution and Shear.
Langmuir
June 2023
Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Deposition of silica microparticles on glass substrates was measured as a function of cationic polymer-anionic surfactant composition and shear rate. Particles were initially deposited in quiescent conditions in different polymer-surfactant compositions, which were chosen based on prior measurements of composition-dependent polymer-surfactant interactions and deposition behavior (up to 0.5 wt % polymer and 12 wt % surfactant).
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