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Background: Intraductal carcinoma of the prostate cancer (IDC-P), as a specific pathological type in prostate cancer which usually implies a poor prognosis. IDC-P morphology can be divided into two subtypes: Pattern 1, sieve like or loose cribriform structures; Pattern 2, solid or dense cribriform structures. The purpose of the study is to identify the impact of IDC-P and its subtypes on the prognosis of patients undergoing post-operative radiotherapy (PORT) after radical prostatectomy (RP) due to localized prostate cancer(PCa).

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DeepFocus: a transnasal approach for optimized deep brain stimulation of reward circuit nodes.

J Neural Eng

January 2025

Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania, 15213-3815, UNITED STATES.

Objective: Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES is primarily used to stimulate superficial brain regions and is unable to reach deeper targets. The spread of injected currents in the head is affected by volume conduction and the additional spreading of currents as they move through head layers with different conductivities, as is discussed in [1].

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Background: This study examines the management and outcomes of large paranasal sinus osteomas (PSO), especially those abutting or encasing critical structures of the skull base and orbit.

Methodology: A multicentric retrospective analysis was conducted between June 2007 and September 2023. The study included surgically treated (regardless the type of approach chosen) PSO, exceeding 3 cm in diameter and/or located in critical anatomical areas.

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Purpose: To evaluate the role of computed tomography-dacryocystography (CT-DCG) in the management of traumatic secondary acquired lacrimal duct obstruction (SALDO) and study its correlation with the intra-operative findings.

Methods: Retrospective interventional case series. Eighty-five lacrimal drainage systems (LDS) of 79 patients diagnosed with traumatic SALDO, who underwent pre-operative CT-DCG, between January 2019 and June 2023, were analyzed.

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Article Synopsis
  • A study of 121 cases of small duct-type intrahepatic cholangiocarcinoma (small duct-iCCA) identified intraductal polypoid neoplasms in 8 cases (6.6%), which showed growth patterns adjacent to mass-forming tumors.
  • These polypoid neoplasms were found to have histological and immunohistochemical similarities to the primary tumors, indicating a shared biliary subtype and reflecting the cancerization of ductal tissues.
  • A comparison with intraductal papillary neoplasm of the bile duct (IPNB) revealed differences, as IPNBs often presented non-invasive characteristics, suggesting that intraductal polypoid neoplasms should
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