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Transferrin-binding domain inserted-adenovirus hexon engineering enables systemic immune evasion and intratumoral T-cell activation.
Theranostics
January 2025
Department of Pharmacology, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Adenovirus-based therapies have encountered significant challenges due to host immunity, particularly from pre-existing antibodies. Many trials have struggled to evade antibody response; however, the efficiency of these efforts was limited by the diversity of antibody Fv-region recognizing multiple amino acid sequences. In this study, we developed an antibody-evading adenovirus vector by encoding a plasma-rich protein transferrin-binding domain.
View Article and Find Full Text PDFFactors associated with cultural sensitivity and global nursing education among nurse educators: A cross-sectional study.
Int J Nurs Stud Adv
June 2025
International Nursing Development, Institute of Science Tokyo (former Tokyo Medical and Dental University), 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan.
Background: Nurse educators must be culturally sensitive to teach cultural care to nursing students effectively.
Objective: To explore the factors associated with cultural sensitivity and global nursing education among nurse educators.
Methods: This was a cross-sectional exploratory study.
Carbon emission of urban vehicles based on carbon emission factor correlation analysis.
Sci Rep
January 2025
Shandong Provincial Communications Planning and Design Institute Group Co., Ltd., Jinan, 250023, China.
The CO emission factor is the basis for analyzing vehicle CO emissions. This study establishes a correlation model between the fuel CO emission factor and the mileage-based CO emission factor using fuel consumption data, then analyzes the fuel consumption and CO emission situation of vehicles in Beijing with the established models. The main research conclusions are as follows: The proposed correlation models are effective for analyzing urban vehicle CO emissions.
View Article and Find Full Text PDFTracking bottom-fishing activities in protected vulnerable marine ecosystem areas and below 800-m depth in European Union waters.
Sci Adv
January 2025
Bloom Association, Paris, France.
Numerous studies have highlighted bottom-contact fishing gears as the primary threat to vulnerable marine ecosystems (VMEs). In November 2022, the European Commission closed 87 VME protection polygons to bottom fishing in European waters. Using public automatic identification system (AIS) data, we found an 81% decrease in bottom-contact fishing effort within these areas in the year following the closures.
View Article and Find Full Text PDFMacrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice.
Sci Transl Med
January 2025
College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
Macrophages play a central role in antitumor immunity, making them an attractive target for gene therapy strategies. However, macrophages are difficult to transfect because of nucleic acid sensors that can trigger the degradation of foreign plasmid DNA. Here, we developed a macrophage-specific editing (MAGE) system by which compact plasmid DNA encoding a CasRx editor can be delivered to macrophages by a poly(β-amino ester) (PBAE) carrier to bypass the DNA sensor and enable RNA editing in vitro and in vivo.
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