Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00004424-197003000-00001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: An intact blood-brain barrier (BBB) is critical for optimal brain health, and even transient or highly localized disruption of the BBB can have devastating consequences for neural functioning. BBB breakdown has been implicated in Alzheimer's Disease (AD) pathogenesis, and elevated BBB permeability has been observed in APOE e4 carriers compared to non-carriers. As prior studies have focused on a priori, AD-vulnerable regions rather than whole-brain analyses, little is understood about broader patterns of BBB breakdown that may relate to AD risk.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Background: Astrocyte reactivity marked by elevations in Glial Fibrillary Acidic Protein(GFAP), was found to increase Phosphorylated Tau181(pTau181) induced neurodegenerative effects in Alzheimer's Disease (Bellaver et al., 2023). Nevertheless, the effect of the GFAP- pTau181 axis in vascular/mixed dementias has yet to be completely elucidated.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Background: The method of obtaining pseudo-cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites of neurodegeneration. However, the obtained early images represent the K1 image rather than cerebral blood flow.
View Article and Find Full Text PDFBackground: Persistent neurological symptoms including cognitive impairment can follow SARS-CoV-2 infection, a condition termed neurological post-acute sequelae of COVID-19 (Neuro-PASC). Structural brain differences have been observed in individuals with Neuro-PASC, raising concern that COVID-19 may promote age-related neurodegeneration. However, the mechanisms by which COVID-19 impairs cognition and its impact on brain aging, remain poorly characterized.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Background: The method of obtaining pseudo-cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites of neurodegeneration. However, the obtained early images represent the K1 image rather than cerebral blood flow.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!