The circulation of rat thymocytes and factors which may control their pathway were studied. Evidence was obtained that intravenously infused thymocytes migrate from blood to spleen and lymph nodes in a manner similar to lymphocytes, though in lesser amounts. Thymocytes, incubated with neuraminidase prior to intravenous infusion, exhibit markedly altered cell migration. Enzyme-treated thymocytes concentrate in the liver with little accumulation in the spleen. Subsequently, however, small numbers of cells migrate to lymph nodes. Trypsin treatment does not alter the migratory pathway of thymocytes. The results suggest that thymocytes migrate from blood to peripheral lymphoid tissue and that sugar constituents may determine the circulatory pathway.
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Article Synopsis
- Cell migration plays a crucial role in the immune system, but it is not well-studied in pregnant animals, despite observed increases in spleen and lymph node sizes during pregnancy.
- In the study, researchers used a mouse model to analyze the movement of PKH26-stained immune cells from pregnant and non-pregnant mice to see how pregnancy affects cell distribution in lymphoid organs.
- Results showed that while more thymocytes were present in females compared to males, the movement of immune cells from pregnant and non-pregnant mice was similar, suggesting that larger spleen and lymph node sizes in pregnant mice may be due to leukocyte retention rather than differences in cell migration.
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