The presence of "natural antibodies" against colicines was detected in the sera of 13 (29.5%) hospitalized recruits aged 20-29 years, 4 (25%) hospitalized males aged 30-49 years, 8 (40%) outpatient elderly subjects aged 50-79 years and in the sera of 15 (27.2%) animals. It is discussed the possible role of colicines as antigenic determinants stimulating the production of "natural antibodies", because of the prolonged and repeated contact of colicinogenic strains with the host animals.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Memory responses to ovalbumin-immunization in Mojave desert tortoises.
Dev Comp Immunol
January 2025
Biology Department, University of Colorado - Pueblo, 2200 Bonforte Ave., Pueblo, CO 81001.
We immunized three groups of Mojave desert tortoises (Gopherus agassizii): a group immunized twice, a group immunized once, and a group sham-immunized. We used the antigen, ovalbumin (OVA), with Freund's adjuvant to elicit antibody responses similar to those induced by extracellular bacteria. All tortoises have relatively high levels of B1 lymphocytes and natural antibodies (NAbs), and the goal of this study was to quantify B2 lymphocyte activity (antibody production and potential proliferation) that occurs in primary and secondary immunizations against this constitutive, first line of humoral defense.
View Article and Find Full Text PDFThe recent landscape of RSV vaccine research.
Ther Adv Vaccines Immunother
January 2025
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX1 2JD, UK.
Respiratory syncytial virus (RSV) causes a significant burden of acute respiratory illness across all ages, particularly for infants and older adults. Infants, especially those born prematurely or with underlying health conditions, face a high risk of severe RSV-related lower respiratory tract infections (LRTIs). Globally, RSV contributes to millions of LRTI cases annually, with a disproportionate burden in low- and middle-income countries (LMICs).
View Article and Find Full Text PDFInsight into distribution and composition of nonhuman N-Glycans in mammalian organs via MALDI-TOF and MALDI-MSI.
Carbohydr Polym
March 2025
Glycomics and Glycan Bioengineering Research Center (GGBRC), College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
The major hurdle of xenotransplantation is the immune response triggered by human natural antibodies interacting with carbohydrate antigens on the transplanted animal organ. Specifically, terminal glycoprotein motifs such as galactose-α1,3-galactose (α-Gal) and N-glycolylneuraminic acid (Neu5Gc) are significant obstacles. Little is known about the abundance and compositions of asparagine-linked complex carbohydrates (N-glycans) carrying these motifs in mammalian organs.
View Article and Find Full Text PDFNatural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids.
J Exp Med
February 2025
School of Basic Medical Sciences, Center for Infection Biology, Tsinghua University, Beijing, China.
The interception of blood-borne bacteria in the liver defines the outcomes of invasive bacterial infections, but the mechanisms of this antibacterial immunity are not fully understood. This study shows that natural antibodies (nAbs) to capsules enable liver macrophage Kupffer cells (KCs) to rapidly capture and kill blood-borne encapsulated bacteria in mice. Affinity pulldown with serotype-10A capsular polysaccharides (CPS10A) of Streptococcus pneumoniae (Spn10A) led to the identification of CPS10A-binding nAbs in serum.
View Article and Find Full Text PDFNatural cross-reactive anti-SARS-CoV-2 antibodies in avian egg yolk.
J Immunol Methods
January 2025
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Article Synopsis
- * Preventative measures, accurate diagnosis, and effective treatments are crucial to controlling COVID-19, and specific antibodies are key for treating patients and preventing new infections.
- * Research indicates avian egg yolk contains natural antibodies (IgY) that can identify and neutralize SARS-CoV-2, suggesting that egg yolk could serve as a cost-effective and readily available source for developing diagnostics and therapies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!