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Multi-faceted examination of a deepwater seamount reveals ecological patterns among coral and sponge communities in the equatorial Pacific.
Sci Rep
January 2025
Department of Biology, Boston University, Boston, MA, USA.
Spatial changes in benthic community structure have been observed across natural gradients in deep-sea ecosystems, but these patterns remain under-sampled on seamounts. Here, we identify the spatial composition and distribution of coral and sponge taxa on four sides of a single central Pacific equatorial "model" seamount within the US EEZ surrounding the Howland and Baker unit of the Pacific Islands Heritage Marine National Monument. This seamount rises from 5,000 + m to mesophotic depths of 196 m, and is influenced by the Equatorial Undercurrent.
View Article and Find Full Text PDFUsing Rasch analysis to assess the latent construct of the Capacity to Work Index in a Swedish working population sample.
Eur J Public Health
January 2025
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at the of University of Gothenburg, Gothenburg, Sweden.
Measurements of capacity to work (CTW) in relation to common mental disorders (CMD) are needed to improve research on determinants for maintained work participation (WP). The aim of this study was to assess the construct validity of the Capacity to Work Index (C2WI) in a heterogenous sample of the Swedish working population. Cross-sectional web survey data among Swedish employees (n = 8201) was used.
View Article and Find Full Text PDFLigand-based cheminformatics and free energy-inspired molecular simulations for prioritizing and optimizing G-protein coupled receptor kinase-6 (GRK6) inhibitors in multiple myeloma treatment.
Comput Biol Chem
January 2025
Drug Discovery and Development Laboratory (DDD Lab), Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Multiple myeloma (MM) is the second most frequently diagnosed hematological malignancy, presenting limited treatment options with no curative potential and significant drug resistance. Recent studies involving genetic knockdown established the crucial role of GRK6 in upholding the viability of MM cells, emphasizing the need to identify potential inhibitors. Computational exploration of GRK6 inhibitors has not been attempted previously.
View Article and Find Full Text PDFMentoring Fellows into Career Educators through a Multispecialty Clinician-Educator Course.
ATS Sch
December 2024
Division of Pulmonary, Critical Care, Sleep Medicine & Physiology and.
Background: Subspecialty fellows are a unique group of trainees for whom there currently exist few opportunities to pursue formal training as clinician-educators, as singular fellowship programs often face significant obstacles to implementing such coursework.
Objective: To develop, implement, and assess a clinician-educator course for fellows from multiple subspecialty fellowships at a single large academic medical center.
Methods: Our course, entitled Fellow as Clinician-Educator, was initiated across numerous fellowship programs from August 2021 to April 2023 at University of California San Diego Health.
Cryoneurolysis and Quadriplegia: A Case Report on Pain and Severe Spasticity Management.
Arch Rehabil Res Clin Transl
December 2024
Vancouver Island Health Authority, Victoria, BC, Canada.
Spasticity, a common symptom after spinal cord injury, often leads to pain, muscle contracture, and compromised daily activities. Cryoneurolysis, a minimally invasive, drug-free procedure for the treatment of pain, is now gaining recognition for treating spasticity. It involves using an ultrasound-guided probe to freeze and destroy overactive target nerves.
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