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Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.
Microb Biotechnol
January 2025
Huadong Medical Institute of Biotechniques, Nanjing, China.
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.
View Article and Find Full Text PDFDisulfiram-induced psychosis still an important clinical entity: A case series.
Ind Psychiatry J
August 2024
Department of Psychiatry, INHS Asvini, Mumbai, Maharashtra, India.
Disulfiram, an FDA-approved medication for treating alcohol dependence syndrome (ADS), is often used surreptitiously, resulting in severe adverse drug reactions such as disulfiram-induced psychosis (DIP). DIP presents diagnostic challenges, despite being perceived as common; however, there is limited literature available on DIP in India. We describe four cases with a history of psychosis in the background of disulfiram exposure.
View Article and Find Full Text PDFSelective Inhibition of Deamidated Triosephosphate Isomerase by Disulfiram, Curcumin, and Sodium Dichloroacetate: Synergistic Therapeutic Strategies for T-Cell Acute Lymphoblastic Leukemia in Jurkat Cells.
Biomolecules
October 2024
Laboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
T-cell acute lymphoblastic leukemia (T-ALL) is a challenging childhood cancer to treat, with limited therapeutic options and high relapse rates. This study explores deamidated triosephosphate isomerase (dTPI) as a novel therapeutic target. We hypothesized that selectively inhibiting dTPI could reduce T-ALL cell viability without affecting normal T lymphocytes.
View Article and Find Full Text PDFProlonged Retention of Albumin Nanoparticles Alleviates Renal Ischemia-Reperfusion Injury through Targeted Pyroptosis.
ACS Appl Mater Interfaces
November 2024
Department of Nephrology, Huai'an Key Laboratory of Chronic Kidney Disease, The Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an 223002, China.
Acute kidney injury (AKI) represents a prevalent and complex clinical event, characterized by irreversible damage to renal tubular epithelial cells and high intensive care unit (ICU) admission rates and mortality. The kidneys are highly susceptible to oxidative stress, inflammation, pyroptosis, and programmed cell death. Pyroptosis poses a significant risk, exacerbating the damage and inflammation of renal tubular cells.
View Article and Find Full Text PDFRole of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome.
Parasit Vectors
October 2024
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.
Article Synopsis
- The study investigates how cuproptosis, a process triggered by copper accumulation, influences the severity of malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) caused by Plasmodium falciparum infection.
- Using a mouse model infected with P. berghei ANKA, researchers assessed the impact of copper ion carrier disulfiram and copper ion chelator tetrathiomolybdate on lung injury and inflammation.
- Results showed increased copper levels and macrophage polarization in the lungs of mice treated with disulfiram, indicating that cuproptosis may play a significant role in the development of MA-ALI/ARDS.
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