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SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer.
Sci Rep
January 2025
Thoracic and GI Malignancies Branch, National Institutes of Health, 10 Center Drive, 2B50C, Bethesda, MD, 20892, USA.
Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis. The protein methyltransferase SET and MYND domain-containing 3 (SMYD3), which trimethylates H3K4, activates gene transcription and enhances several oncogenic pathways, including epithelial-mesenchymal transition and cell cycle related pathways, in various cancer types. It was also recently shown that SMYD3 is overexpressed in HPV-negative HNSCC, and represses the expression of type I IFN response genes, contributing to resistance to anti-PD-1 checkpoint blockade in this disease.
View Article and Find Full Text PDFSurgical management of children with Burkitt's lymphoma involving the gastrointestinal tract.
Pediatr Surg Int
December 2024
Department of Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Purpose: To investigate the clinical characteristics and surgical management of children with Burkitt's lymphoma (BL) involving the gastrointestinal tract.
Methods: A retrospective analysis was conducted on 87 pediatric patients diagnosed with BL involving the gastrointestinal tract and treated surgically at Beijing Children's Hospital (2008-2022). All patients were histopathologically confirmed with BL and diagnosed with gastrointestinal involvement through imaging studies and surgery.
Atypical presentation of oral Burkitt lymphoma in an adult: a case report.
J Med Case Rep
December 2024
Department of Oral Surgery, Faculty of Dentistry, Mohammed V University, Rabat, Morocco.
Introduction: Burkitt lymphoma is an aggressive form of non-Hodgkin B cell lymphoma. Oral lesions often are a component of the disseminated disease process that may involve regional lymph nodes or may at times represent the primary extranodal form of the disease. However, isolated oral Burkitt lymphoma in adults is extremely rare.
View Article and Find Full Text PDFHow I diagnose high-grade B-cell lymphoma.
Am J Clin Pathol
December 2024
Mayo Clinic Arizona, Phoenix, AZ, US.
Objectives: High-grade B-cell lymphoma (HGBL), introduced in the 2016 World Health Organization (WHO) revised fourth edition classification, included cases defined by MYC and BCL2 and/or BCL6 rearrangements or by high-grade morphology. Diagnostic criteria and nomenclature for these lymphomas were refined in the 2022 WHO fifth edition (WHO-5) classification and International Consensus Classification (ICC). This review describes our approach to the diagnosis of HGBL.
View Article and Find Full Text PDFA Diagnostic Approach in Large B-Cell Lymphomas According to the Fifth World Health Organization and International Consensus Classifications and a Practical Algorithm in Routine Practice.
Int J Mol Sci
December 2024
Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.
In this article, we provide a review of large B-cell lymphomas (LBCLs), comparing the recently published fifth edition of the WHO classification and the International Consensus Classification (ICC) on hematolymphoid tumors. We focus on updates in the classification of LBCL, an heterogeneous group of malignancies with varying clinical behaviors and different pathological and molecular features, providing a comparison between the two classifications. Besides the well-recognized diagnostic role of clinical, morphological and immunohistochemical data, both classifications recognize the ever-growing impact of molecular data in the diagnostic work-up of some entities.
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