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PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells.
Curr Top Med Chem
January 2025
Universidade Federal Fluminense, Instituto de Biologia, Laboratório de Virologia Molecular e Biotecnologia Marinha, 24210-200, Niterói-RJ, Brasil.
Background: Zika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain- Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence and the resulting epidemics in 2016, the search for effective antiviral drugs has become absolutely necessary.
Methods: In this study, we examined the potential of naphthoquinone derivatives that have a sulfonamide or sulfonate group to inhibit ZIKV replication in primary cultured neurons and in Vero cells.
Analysis methods for covariate-constrained cluster randomized trials with time-to-event outcomes.
BMC Med Res Methodol
January 2025
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
Background: Cluster randomized trials, which often enroll a small number of clusters, can benefit from constrained randomization, selecting a final randomization scheme from a set of known, balanced randomizations. Previous literature has addressed the suitability of adjusting the analysis for the covariates that were balanced in the design phase when the outcome is continuous or binary. Here we extended this work to time-to-event outcomes by comparing two model-based tests and a newly derived permutation test.
View Article and Find Full Text PDFThermal variation influences the transcriptome of the major malaria vector Anopheles stephensi.
Commun Biol
January 2025
Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
The distribution and abundance of ectothermic mosquitoes are strongly affected by temperature, but mechanisms remain unexplored. We describe the effect of temperature on the transcriptome of Anopheles stephensi, an invasive vector of human malaria. Adult females were maintained across a range of mean temperatures (20 °C, 24 °C and 28 °C), with daily fluctuations of +5 °C and -4 °C at each mean temperature.
View Article and Find Full Text PDFCharacterization of some selected macroalgae extracts and assessment of their insecticidal and genotoxicity in Culex pipiens L. mosquito larvae.
Sci Rep
January 2025
Economic Entomology Department, Faculty of Agriculture, Mansoura University, Mansoura, 35516, Egypt.
The continual use of synthetic insecticides to control mosquito larvae has severe implications for human health and the ecosystem, highlighting the need for alternative natural insecticides. Macroalgae may be a good alternative because of their biologically active metabolites with distinctive chemical structures that have been reported for their insecticidal properties. The study aimed to investigate the potential of different extracts from Jania rubens (Linnaeus) J.
View Article and Find Full Text PDFEpidemiological feature of imported malaria in Taiwan during the 2014-to-2020 period.
Medicine (Baltimore)
January 2025
School of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Although the World Health Organization (WHO) certified Taiwan as being malaria-free in 1965, there are reports of a few imported cases each year by travelers who visit malaria-endemic areas. This study examined the epidemiology of imported malaria cases in Taiwan from 2014 to 2020, utilizing national surveillance data from the Taiwan Centers for Disease Control. Malaria cases were confirmed through the application of standard laboratory methods.
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