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Assessment of Skin Photoallergy Risk in Cosmetics Containing Herbal Extract Ingredients.
Skin Pharmacol Physiol
January 2022
Department of Dermato-Venereology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Background/objective: In recent years, herbal extracts are becoming increasingly popular ingredients added in cosmetics; however, the assessment of their potential adverse effects on the skin remains unclear. As Coptis, Phellodendron amurense, curcumin, and shikonin are herbs currently used in cosmetic ingredients, the aim of this study was to assess their skin photoallergy (PA) potential and the concentrations at which they could safely be used.
Methods: In the patch test, Coptis, P.
Objectives: The multifunctional drug niclosamide (NSD), extensively employed therapeutically, is a frequent pollutant of surface waters. Considering the environmental importance of photodegradative processes for this type of contaminant, the kinetic and mechanistic aspects of the possible visible-light-mediated photooxidation of NSD were studied under naturalistic conditions.
Methods: The visible-light absorber riboflavin (vitamin B2) was employed as a photosensitizer.
Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells.
Mutat Res
July 2011
Takeda Pharmaceutical Company Limited, Jusohonmachi 2-chome, Yodogawa-ku, Osaka, Japan.
Photochemical genotoxicity was evaluated in human keratinocyte NCTC2544 cells. The cells were pre-treated with photogenotoxic or pseudophotoclastogenic chemicals and irradiated with a solar-simulator for 50min at a total UV dose of 5J/cm(2) or placed in the dark for the same period. After washing, the cells were cultured for 1.
View Article and Find Full Text PDFPhotoallergic contact dermatitis.
G Ital Dermatol Venereol
October 2009
Department of Internal Medicine Immunology and Infectious Diseases, University of Bari, Bari, Italy.
Photoallergic contact dermatitis (PCD) is a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in subjects previously sensitized to the same substance. For the development of PCD, irradiation with ultraviolet (UV) radiations, usually UVA, is required to create a complete antigen, and the culprit substance needs to be within the skin at the time of UVA exposure. The incidence of PCD in the general population is unknown and is considered uncommon.
View Article and Find Full Text PDFAllergic hypersensitivity skin reactions following sun exposure.
Coll Antropol
October 2008
Department of Dermatology and Venereology, University Hospital Sestre milosrdnice, Zagreb, Croatia.
Article Synopsis
- Photoallergic dermatoses are skin reactions triggered by UV exposure, where certain substances (photosensitizers and photoallergens) activate the immune system, leading to rashes on sun-exposed areas.
- A key condition in this group is photoallergic contact dermatitis, which arises from direct contact with allergens during UV exposure and manifests as skin lesions due to an immune response.
- Other types include solar urticaria (a rare, immediate skin reaction), polymorphous light eruption (a seasonal skin condition), and hydroa vacciniforme (which causes vesicular eruptions and scarring), though their exact causes often remain unidentified.
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