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Iatrogenic Proximal Urethro-Rectal Perforation During Foley Catheter Insertion.
Case Rep Surg
January 2025
Department of General Surgery, University of Balamand, Beirut, Lebanon.
Iatrogenic urethral-rectal perforation represents a rare but severe complication arising from medical interventions, notably highlighted in the context of Foley catheter insertion. This case report outlines the presentation, diagnosis, management, and outcomes of a 71-year-old male patient who experienced iatrogenic rectal perforation during the routine insertion of a Foley catheter, against the backdrop of several predisposing factors, such as atrial fibrillation, valvular disease, benign prostatic hyperplasia, urethral stenosis, and colorectal cancer with liver metastasis. The inadvertent creation of a rectourethral fistula during the procedure led to an urgent multidisciplinary approach involving surgery and postoperative management, including fecal and urine diversion and antibiotic therapy.
View Article and Find Full Text PDFThe Potential Role of Zika and Dengue Virus Infection in the Urogenital System Disorders: An Overview.
Rev Med Virol
January 2025
Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, China.
Arboviruses currently are regarded as a major worldwide public health concern. The clinical outcomes associated with this group of viruses may vary from asymptomatic infections to severe forms of haemorrhagic fever characterised by bleeding disorders. Similar to other systemic viral infections, arboviruses can either directly or indirectly affect different parts of the body, such as the urogenital system.
View Article and Find Full Text PDFEpithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns.
Dev Biol
January 2025
Institute for Stem Cell Science and Regenerative Medicine (iBRIC-inStem), GKVK-Post, Bellary Road, Bengaluru, Karnataka 560065, India. Electronic address:
Article Synopsis
- The lower urinary tract, consisting of the bladder and urethra, develops from the cloaca, with the bladder forming from the urogenital sinus and the urethra extending into the genital tubercle.
- Engineering a fully functional bladder lining is challenging, and the urethral epithelium's immune roles are under-researched, highlighting the need for a better understanding of the epithelial and mesenchymal interactions that drive development.
- This study identified specific genes involved in bladder and urethra development in mice, revealing differences in gene expression patterns related to sex and offering insights for future regenerative therapies.
Swiss Consensus on Prenatal and Early Postnatal Urinary Tract Dilation: Practical Approach and When to Refer.
Children (Basel)
December 2024
Nephrology Unit, Paediatric Specialties Division, Geneva University Hospitals (HUG), 1205 Geneva, Switzerland.
Urinary tract dilations (UTDs) are the most frequent prenatal renal anomaly. The spectrum of etiologies causing UTD ranges from mild spontaneously resolving obstruction to severe upper and lower urinary tract obstruction or reflux. The early recognition and management of these anomalies allows for improved renal endowment prenatally and ultimately better outcome for the child.
View Article and Find Full Text PDFCellular cartography reveals mouse prostate organization and determinants of castration resistance.
bioRxiv
December 2024
Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109.
Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single-cell RNA sequencing, single-cell multiomics, and spatial transcriptomics to define the transcriptional, epigenetic, and spatial basis of cell identity and castration response in the mouse prostate. Leveraging these data along with a meta-analysis of human prostates and prostate cancer, we identified cellular orthologs and key determinants of ADT response and resistance.
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