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Previous strength training attenuates ouabain-induced bipolar disorder-related behaviors and memory deficits in rats: Involvement of hippocampal ERK/CREB and PI3K/AKT/mTOR pathways.
Neurochem Int
December 2024
Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS, Brazil; Physical Education Undergraduation, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address:
Bipolar disorder (BD) is a central nervous system condition that is typified by fluctuations in mood, oscillating between depressive and manic, and/or hypomanic episodes. The objective of this study was to test the hypothesis that strength training may act as a potent protector against behavioral and neurochemical changes induced by BD. A strength training protocol was performed with adult male Wistar rats, and seven days following the conclusion of training, a single ouabain injection was administered.
View Article and Find Full Text PDFAntiviral and immunomodulatory effects of ouabain against congenital Zika syndrome model.
Mol Ther
December 2024
Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA. Electronic address:
Zika virus (ZIKV) is an arbovirus associated with neurological disorders accompanying congenital infections. With no vaccine or antiviral approved, there is an urgent need for the development of effective antiviral agents against ZIKV infection. We evaluated the anti-ZIKV and immunomodulatory activity of ouabain, a Na/K-ATPase inhibitor known to have immunomodulatory and antiviral activities, using human neural stem and progenitor cells (hNS/PCs) and a murine model of congenital Zika syndrome (CZS).
View Article and Find Full Text PDFRecovery from spreading depolarization is slowed by aging and accelerated by antioxidant treatment in locusts.
J Neurophysiol
January 2025
Department of Biology, Queen's University, Kingston, Ontario, Canada.
Spreading depolarization (SD) temporarily shuts down neural processing in mammals and insects. Age is a critical factor for predicting the consequences of SD in humans. We investigated the effect of aging in an insect model of SD and explored the contribution of oxidative stress.
View Article and Find Full Text PDFGiant miniature endplate potentials at vertebrate neuromuscular junctions: A review.
Eur J Neurosci
December 2024
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA.
An unusually large amplitude spontaneous miniature endplate potentials (gMEPPs) occur naturally at low frequency at the vertebrate neuromuscular junction. Unlike the normal miniature endplate potentials (nMEPPs), these gMEPPs have long duration and long time to peak. More strikingly, gMEPPs seem to be independent of extracellular and intracellular Ca and have a greater temperature sensitivity than nMEPPs.
View Article and Find Full Text PDFMale Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3-4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters.
Int J Mol Sci
November 2024
Graduate Program in Translational Biomedicine (BIOTRANS), Grande Rio University (UNIGRANRIO), Duque de Caxias 25071-202, Brazil.
The central aim of this study was to investigate whether male Wistar rats chronically fed a high-fat diet (HFD) over 106 days present high levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and Na and Ca transport alterations in the left ventricle, together with dyslipidemia and decreased glucose tolerance, and to investigate the influence of Ang-(3-4). The rats became moderately overweight with an expansion of visceral adiposity. Na-transporting ATPases, sarco-endoplasmic reticulum Ca-ATPase (SERCA2a), and the abundance of Angiotensin II receptors were studied together with lipid and glycemic profiles from plasma and left-ventricle echocardiographic parameters fractional shortening (FS) and ejection fraction (EF).
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