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A review and perspective paper: Ras oncogene gets modest, from kingpin to mere henchman.
Cell Mol Life Sci
October 2024
Université Paris Cité, Thoracic Oncology Department, Hôpital Bichat, AP-HP.Nord & U830 Inserm Stress and Cancer Laboratory, Institut Curie, 26 rue d'Ulm, 75005, Paris, France.
The concomitant activation of both the YAP1 co-transcription factor and RAS GTPases is a hallmark of several aggressive cancers, though the intricacies of their relationship and implications for oncogenesis are still poorly understood. This review has presented a cooperative model where YAP1 and RAS are not independently acting oncogenes but rather interdependently acting ones, with each fulfilling an essential role within the oncogenic process. YAP1 is responsible for initiating the expression of key proteins that contribute to various cancer traits.
View Article and Find Full Text PDFMicroangiopathic thrombocytopenia caused by vitamin B12 deficiency responding to plasma exchange.
Br J Haematol
October 2024
Department of Medical Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, California, USA.
Article Synopsis
- A young African American female presented with symptoms of normocytic microangiopathic hemolytic anemia, elevated lactate dehydrogenase, and low platelet count, suggesting thrombotic thrombocytopenic purpura (TTP).
- After initial treatment with therapeutic plasma exchanges (TPE), she relapsed and was diagnosed with pernicious anemia, characterized by low vitamin B12 and megaloblastic bone marrow.
- Her condition improved after receiving intramuscular B12 and stopping TPE, highlighting the importance of recognizing vitamin B12 deficiency, which can mimic TTP symptoms.
Causes and Risk Factors of Vitamin B12 Deficiency at the Bookends of Life, From Infancy to Old Age.
Food Nutr Bull
June 2024
University of California, Davis, CA, USA.
The causes and risk factors of vitamin B12 deficiency are many and varied. Importantly, they vary considerably across the lifespan, from infancy to old age. The complexity of the physiology of vitamin B12 bespeaks the myriad of possible causes of deficiency and possible disruptions of its functional integrity.
View Article and Find Full Text PDFCo-existence of ANCA-associated vasculitides with immune-mediated diseases: a single-center observational study.
Rheumatol Int
August 2024
Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland.
Background: Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) is a group of systemic necrotizing small vessel autoimmune diseases, with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) being the two most common. The co-existence of AAV with different immune-mediated diseases (autoimmune disesases - AID) might affect the clinical presentation of the primary disease. The purpose of the study was to assess the co-existence of AAV with AID and to investigate whether it affects the characteristics and the course of AAV.
View Article and Find Full Text PDFA Case of Vitiligo Combined with Systemic Lupus Erythematosus Treated with Tofacitinib.
Clin Cosmet Investig Dermatol
March 2024
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People's Republic of China.
Vitiligo is a skin depigmentation disease resulting from melanocyte destruction and often co-occurring with autoimmune disorders like hyperthyroidism, alopecia areata, pernicious anemia, and systemic lupus erythematosus (SLE). Although various traditional treatments exist for vitiligo, their effectiveness varies considerably. This report presents a unique case of a vitiligo patient with concomitant systemic lupus erythematosus.
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