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Uterine Transplant Optimization From a Preclinical Donor Model With Controlled Cardiocirculatory Arrest.
Transplant Direct
January 2025
CRT2I UMR 1064, Nantes Université, CHU Nantes, INSERM, Centre for Research in Transplantation and Translational Immunology, Nantes, France.
Background: Uterus transplantation from deceased donors offers a promising solution to the organ shortage, but optimal preservation methods are crucial for successful outcomes. Our primary objective is to conduct an initial assessment of the contribution of oxygenated hypothermic perfusion in uterine transplantation.
Methods: We performed a preclinical study on a porcine model of controlled donation after circulatory death (60 min warm ischemia).
Sex-specific responses of central artery stiffness to cold pressor test-mediated sympathetic activation.
Physiol Behav
February 2025
Université de Franche-Comté, SINERGIES, F-25000 Besançon, France; Université de Franche-Comté, Plateforme Exercice Performance Santé Innovation, F-25000 Besançon, France; Faculty of Science, Department of Biological Sciences, Thompson Rivers University Kamloops, British Columbia, Canada. Electronic address:
Considerable attention has been devoted to investigating whether acute activation of the sympathetic nervous system, triggered by daily life stressors, increases central artery stiffness (CAS). Overt sex differences in sympathetic neurovascular transduction lead to distinct cardiovascular responses to sympathoexcitation in men versus women. Our study aimed to determine if the cold pressor test (CPT), chosen to simulate highly painful stressors individuals encounter daily, would induce CAS augmentation in a sex-balanced cohort of young individuals and whether any observed CAS increase would differ between sexes.
View Article and Find Full Text PDFDrug interactions in a coronary care unit: Adversity or therapeutic success?
Enferm Intensiva (Engl Ed)
November 2024
Universidade Federal de São João Del Rei (UFSJ), Divinópolis, MG, Brazil. Electronic address:
Objectives: To analyze the prevalence and factors associated with potential clinically significant drug interactions (pDDIs) in a coronary care unit and to describe clinical management for reducing the occurrence of pDDIs.
Methods: A cross-sectional and analytical study was conducted on 120 patients aged≥18 years and who had used two or more medications who were admitted to coronary care unit at a high-complexity hospital in Campinas, São Paulo, Brazil. Participants were recruited consecutively from May 2018 to April 2019.
Hemodynamic Effects and Clinical Outcomes of Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO) in Cardiogenic Shock.
Am J Cardiol
February 2025
Structural Heart Disease, Heart and Vascular Services, Henry Ford Hospital, Detroit, Michigan.
Left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) in cardiogenic shock (CS) is a novel mechanical cardiocirculatory support strategy that provides robust cardiocirculatory support and simultaneous left and right atrial venting by way of a multifenestrated transeptal catheter. We performed a single-center retrospective analysis of all patients aged ≥18 years with CS who underwent LAVA-ECMO at a quaternary care institution from 2018 to 2023. Clinical outcomes and prehemodynamics and posthemodynamics were evaluated.
View Article and Find Full Text PDFArrhythmias May Hide a Genetic Cardiomyopathy in Left Ventricular Hypertrabeculation in Children: A Single-Center Experience.
Children (Basel)
October 2024
Pediatric Cardiology and Cardiac Arrhythmias Complex Unit, Bambino Gesù Children's Hospital IRCCS, 00050 Rome, Italy.
Article Synopsis
- Left ventricular hypertrabeculation (LVHT) is a heart condition that can lead to various symptoms, including serious issues like heart failure and arrhythmias, making it difficult to identify which cases are benign versus pathological.
- A study analyzed 140 pediatric patients with LVHT over ten years, and found that 23.6% of them experienced arrhythmias, with various types identified, including supraventricular and ventricular arrhythmias.
- Results indicated a significant relationship between specific genetic variants (class 4 or 5) and the occurrence of arrhythmias, while the patients generally had good outcomes, with no reported sudden cardiac deaths.
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