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Sophoricoside Inhibited Glioblastoma Cell Progression Through Activated AMP-Activated Protein Kinase (AMPK).
Mol Carcinog
January 2025
Department of Neurosurgery, Huanggang Central Hospital of Yangtze University, Huanggang, China.
Glioblastoma (GBM) is the most common malignant primary brain tumor, with a mean survival of less than 2 years. Unique brain structures and the microenvironment, including blood-brain barriers, put great challenges on clinical drug development. Sophoricoside (Sop), an isoflavone glycoside isolated from seeds of Sophora japonica L.
View Article and Find Full Text PDFThe signification of the principle of constancy in Freud's psychoanalysis.
Int J Psychoanal
December 2024
Independent Researcher.
This article examines the signification of the principle of constancy in Freud's pre-psychoanalytic drafts and papers and in . It is argued that Freud's principle differs from seemingly similar principles proposed by Breuer and Fechner, and that it constitutes an assumption about the maintaining of a constant amount of mobile biophysical energy whose purpose is to return to equilibrium, but, proceeding from the primary functions of discharge (principle of inertia) and accumulation (exigencies of life), to consolidate an asymmetry within the nervous system. This gives rise to a set of quasi-psychological dualisms: an energetic dualism between kinetic and tonic energy; a systemic dualism between impermeable and permeable neurons; and a processual dualism between courses of the excitation with and without the inhibiting influence of the ego.
View Article and Find Full Text PDFAbdominal Aortic Aneurysm with Primary Cold Agglutinin Disease Treated with Endovascular Aortic Repair.
Ann Vasc Dis
January 2025
Department of Surgery, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Hiroshima, Japan.
Cold agglutinin disease (CAD) is a rare and autoimmune hemolytic disorder caused by the presence of cold-reacting autoantibodies against red blood cells. An abdominal aortic aneurysm (AAA) is a potentially life-threatening condition. This report describes an 83-year-old man with AAA who was diagnosed with primary CAD 9 years before undergoing AAA surgery.
View Article and Find Full Text PDFDevelopment and validation of a screening tool for sepsis without laboratory results in the emergency department: a machine learning study.
EClinicalMedicine
February 2025
Emergency Centre, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Background: Sepsis is a significant health burden on a global scale. Timely identification and treatment of sepsis can greatly improve patient outcomes, including survival rates. However, time-consuming laboratory results are often needed for screening sepsis.
View Article and Find Full Text PDFAutologous Fat Grafting in Hand Surgery: A Systematic Review.
Plast Reconstr Surg Glob Open
January 2025
Texas Tech University Health Sciences Center, Department of Orthopaedic Surgery, Lubbock, TX.
Background: Autologous fat grafting (AFG) has gained popularity in both cosmetic and reconstructive surgery, including hand surgery, due to its regenerative potential and dual benefits of enhancing aesthetics and function. This systematic review aims to evaluate the efficacy of AFG in treating various hand pathologies.
Methods: A systematic review was conducted following PRISMA guidelines.
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