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Development and thorough evaluation of a multi-omics sample preparation workflow for comprehensive LC-MS/MS-based metabolomics, lipidomics and proteomics datasets.
Talanta
December 2024
Hyphenated Mass Spectrometry Laboratory, Faculty of Science, University of Technology Sydney, PO Box 123, Broadway, 2007 NSW, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, PO Box 123, Broadway, 2007 NSW, Australia.
The importance of sample preparation selection if often overlooked particularly for untargeted multi-omics approaches that gained popularity in recent years. To minimize issues with sample heterogeneity and additional freeze-thaw cycles during sample splitting, multiple -omics datasets (e.g.
View Article and Find Full Text PDFInsights into the renal pathophysiology in Hermansky-Pudlak syndrome-1 from urinary extracellular vesicle proteomics and a new mouse model.
FEBS Lett
December 2024
Section on Human Biochemical Genetics, Medical Genetics Branch, NHGRI, National Institutes of Health, Bethesda, MD, USA.
Hermansky-Pudlak syndrome type 1 (HPS-1) is a rare, autosomal recessive disorder caused by defects in the biogenesis of lysosome-related organelles complex-3 (BLOC-3). Impaired kidney function is among its clinical manifestations. To investigate HPS-1 renal involvement, we employed 1D-gel-LC-MS/MS and compared the protein composition of urinary extracellular vesicles (uEVs) from HPS-1 patients to normal control individuals.
View Article and Find Full Text PDFMagnesium and silicon recovery from chrysotile asbestos waste of the deposit Zhitikara, Kazakhstan.
Sci Rep
December 2024
Republican State Enterprise National Center for Complex Processing of Mineral Raw Materials of the Republic of Kazakhstan, RSE "NC CPMRM RK", Zhandosov st., 67, Almaty, 050036, Kazakhstan.
Waste generated during asbestos manufacturing contains substantial quantities of iron, nickel, magnesium, and silicon. The existing techniques for processing chrysotile-asbestos waste (CAW) cannot fully recover these elements. Therefore this paper presents a hydrometallurgical method for processing the CAW of the Zhitikara deposit in the Kostanay region of Kazakhstan.
View Article and Find Full Text PDFExperimental investigation of biopolymers influences on rheology and filtration properties of water-based drilling fluids.
Heliyon
December 2024
Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Pipe-stuck, filtrate volume, and formation damage during the drilling operation are directly related to the poor performance of drilling fluids. Hence, considerable attention is required to improve the filtration and rheological properties of drilling fluids and achieve industrial and environmental qualification standards. This study experimentally investigates the impact of Pectin and Astragalus gum biopolymers on the filtration and rheological properties of the water-based drilling fluid (WBDF).
View Article and Find Full Text PDFRevealing O-acetylhomoserine sulfhydrylase involved in direct sulfhydrylation pathway in Clostridium tetani.
Biochimie
December 2024
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.
Bacterial methionine biosynthesis is an attractive target for research due to its central role in cellular metabolism, as most steps of this pathway are missing in mammals. Up to now little is known about sulfur metabolism in pathogenic Clostridia species, making the study of the enzymes of Cys/Met metabolism in Clostridium tetani particularly relevant. Analysis of the C.
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