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Advanced Automated Model for Robust Bone Marrow Segmentation in Whole-body MRI.
Acad Radiol
January 2025
Division of Radiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany (F.B., M.G., H.P.S., S.D.); Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120 Heidelberg, Germany (T.F.W., M.W.).
Rationale And Objectives: To establish an advanced automated bone marrow (BM) segmentation model on whole-body (WB-)MRI in monoclonal plasma cell disorders (MPCD), and to demonstrate its robust performance on multicenter datasets with severe myeloma-related pathologies.
Materials And Methods: The study cohort comprised multi-vendor, multi-protocol imaging data acquired with varying field strength across 8 different centers. In total, 210 WB-MRIs of 207 MPCD patients were included.
Qualitative Comparison of Cultured Skin Microbiota From the Inguinal Region of Obese and Nonobese Patients Eligible for Hip Arthroplasty.
Arthroplast Today
December 2024
Institute for Hygiene and Microbiology, University of Wuerzburg, Würzburg, Germany.
Background: With the rising prevalence of obesity, surgeons are frequently confronted with the problem of treating osteoarthritis of the hip via arthroplasty (total hip arthroplasty) in severely obese patients. To reduce the surgical impact, minimal-invasive approaches are often chosen. For this reason, the direct anterior approach has gained popularity but is suspected of leading to more wound complications in obese patients, especially by Gram-negative pathogens.
View Article and Find Full Text PDFRevisiting the neuroanatomy of Massetognathus pascuali (Eucynodontia: Cynognathia) from the early Late Triassic of South America using Neutron Tomography.
Naturwissenschaften
January 2025
Programa de Pós-Graduação em Biodiversidade Animal, Universidade Federal de Santa Maria, Av. Roraima 1000, 97105-900, Santa Maria, RS, Brazil.
This paper analyzes the paleoneurology (cranial endocast and maxillary canal) of Massetognathus pascuali, an iconic non-mammaliaform cynodont from the early Late Triassic of South America, using Neutron Tomography. The application of neutron tomography holds the potential for uncovering more refined anatomical and quantitative data. The newly examined cranial endocast shows a forebrain with a tubular shape without an interhemispheric fissure, presence of a pineal body (with a closed parietal foramen), and a marked unossified zone.
View Article and Find Full Text PDF"Identity politics" is economic policy.
Science
January 2025
Rohini Pande is the Henry J. Heinz II Professor of Economics and director of the Economic Growth Center, Yale University, New Haven, CT, USA.
In the wake of the November 2024 US election, several commentators have suggested that the US Democratic Party abandon its commitment to so-called "identity politics," which they identify as elitist, condescending, and divisive. They argue that rather than focusing on these "cultural" issues, progressives should prioritize economic concerns. Yet identity politics, at a fundamental level, is driven, and dominated, by economic concerns.
View Article and Find Full Text PDFRelationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study.
Nat Ment Health
January 2025
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14-23 years) of ED-related psychopathology and brain maturation. Clustering analyses at age 23 years ( = 996) identified 3 eating groups: restrictive, emotional/uncontrolled and healthy eaters.
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