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Evaluation of the merit of ethanolic extract of as an anti-cancer agent in human colon cancer cell lines (HCT-116).
F1000Res
January 2025
Department of Biochemistry, Kastubra Medical College Manipal, Maniapl Academy of Higher Education, Manipal, Karnataka, India.
Background: Colon cancer is the third most common cancer type worldwide. Novel alternative therapeutic anti-cancer drugs against colon cancer with less toxicity are to be explored . This study was aimed to explore the anti-proliferative and anti-migratory activity of various fractions of ethanolic leaf extract on human colon cancer cell lines (HCT-116) and to explore the potential molecular targets from the most potent plant extract fraction.
View Article and Find Full Text PDFTc radiolabeling of palm shell charcoal: A preliminary study for potential lung ventilation scintigraphy agent.
Appl Radiat Isot
January 2025
Department of Chemistry, Universitas Indonesia, Depok, 16424, Indonesia.
To investigate the potential of activated carbon from palm kernel shell waste for Tc-radiolabeled nanocarbon aerosol, a new production technology for carbon-based Tc-radioaerosol from such a waste was developed. Treated-palm shell charcoal (t-PSC) was prepared by hydrothermal method to increase the surface area, followed by Tc radiolabelling optimization. The optimal Tc radiolabeling conditions resulted in an adsorption capacity of 21.
View Article and Find Full Text PDFExercise Training in Heart Failure: Current Evidence and Future Directions.
J Clin Med
January 2025
School of Medicine, University of Liverpool, Liverpool L69 3GE, UK.
Heart Failure (HF) is a prevalent condition which places a substantial burden on healthcare systems worldwide. Medical management implemented with exercise training (ET) plays a role in prognostic and functional capacity improvement. The aim of this review is to determine the effect of exercise training (ET) on HFpEF and HFrEF patients as well as exercise modality recommendations in frail and sarcopenic subpopulations.
View Article and Find Full Text PDFAntimicrobial Activities of Polysaccharide-Rich Extracts from the Irish Seaweed , Generated Using Green and Conventional Extraction Technologies, Against Foodborne Pathogens.
Mar Drugs
January 2025
Section of Food and Nutrition, School of Agriculture and Food Science, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
A rise in antimicrobial resistance coupled with consumer preferences towards natural preservatives has resulted in increased research towards investigating antimicrobial compounds from natural sources such as macroalgae (seaweeds), which contain antioxidant, antimicrobial, and anticancer compounds. This study investigates the antimicrobial activity of compounds produced by the Irish seaweed against and , bacterial species which are relevant for food safety. Microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), ultrasound-microwave-assisted extraction (UMAE), and conventional extraction technologies (maceration) were applied to generate extracts from , followed by their preliminary chemical composition (total phenolic content, total protein content, total soluble sugars) and antimicrobial activity (with minimum inhibitory concentration determined by broth microdilution methods), examining also the molecular weight distribution (via high performance size exclusion chromatography) and oligosaccharide fraction composition (via high-performance liquid chromatography) of the polysaccharides, as they were the predominant compounds in these extracts, aiming to elucidate structure-function relationships.
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