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Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization.
J Inflamm Res
January 2025
Department of Internal Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, People's Republic of China.
Purpose: Serum uric acid (SUA) is primarily produced through the hydrolysis of purines in the liver, with its excretion largely handled by the kidneys. Urate transporter 1 (URAT1) inhibitors are known to enhance uric acid elimination via the kidneys, but they also increase the risk of kidney stone formation. Currently, xanthine oxidase (XO) inhibitors are the predominant uric-lowering medications on the market.
View Article and Find Full Text PDFEffects and mechanisms of theabrownin from black tea in improving hyperuricemia: Evidence from animal study and clinical trial.
Int J Biol Macromol
December 2024
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen 361102, China.
Article Synopsis
- Hyperuricemia (HUA) is a condition where excess uric acid builds up in the body, and Theabrownin (TB), a compound from black tea, may help improve this condition.
- TB was found to lower uric acid levels and reduce kidney damage in HUA mice by inhibiting an enzyme (xanthine oxidase) and enhancing uric acid transport in the kidneys.
- A clinical trial with HUA patients indicated that consuming TB daily for 12 weeks effectively decreased uric acid levels without negative side effects.
colonic fermentation of fermented Radix Astragali by and anti-hyperuricemia mechanism based on network pharmacology and experiment verification.
Front Nutr
December 2024
School of Pharmaceutical Science, Binzhou Medical University, Yantai, China.
Aim: This research aimed to probe the effects of fecal microbiota and on the metabolism of Radix Astragali (RA) and solid fermenting Radix Astragali (FRA). It further explores pharmacological effects of RA, , and FRA on HUA mouse model and the mechanisms in HUA treatment.
Methods: Fecal microbiota and were used to ferment FRA and RA in vitro to probe the impacts of microbiota on the metabolism of active compound.
Study on the mechanism of lactic acid bacteria and their fermentation broth in alleviating hyperuricemia based on metabolomics and gut microbiota.
Front Nutr
December 2024
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi, China.
Introduction: Hyperuricemia (HUA) is a metabolic disease caused by purine metabolism disorders in the body. Lactic acid bacteria (LAB) and their fermentation broth have the potential to alleviate hyperuricemia, but the potential mechanism of action is still unclear.
Methods: The LAB with high inhibitory activity against xanthine oxidase (XOD) were screened out.
Serum uric acid and nonalcoholic fatty liver disease.
Front Endocrinol (Lausanne)
December 2024
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.
Nonalcoholic fatty liver disease (NAFLD) is characterized by over 5% hepatic fat accumulation without secondary causes. The prevalence of NAFLD has escalated in recent years due to shifts in dietary patterns and socioeconomic status, making it the most prevalent chronic liver disease and a significant public health concern globally. Serum uric acid (SUA) serves as the end product of purine metabolism in the body and is intricately linked to metabolic syndrome.
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