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Atypical ulcer arising on stasis dermatitis: achromic melanoma.
Wounds
February 2022
Ospedale Civile di Livorno, Livorno, Italy.
Introduction: Due to venous insufficiency, a vascular ulcer frequently occurs with the progression of stasis dermatitis. Achromic melanoma, a rare form of pigmentless melanoma frequently located on the sole of the foot, is often and easily confused with a typical wound. Diagnosis of ulcerated achromic melanoma is thus often delayed and associated with a poor prognosis.
View Article and Find Full Text PDFLymphocytic thrombophilic arteritis with lower-limb ulcers.
An Bras Dermatol
June 2021
Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Lymphocytic thrombophilic arteritis is a recently described entity, histopathologically characterized by lymphocytic vasculitis that affects the arterioles of the dermo-hypodermic junction, associated with deposition of fibrin and a luminal fibrin ring. A 49-year-old female patient presented with achromic maculae and a well-defined ulcer on the medial aspect of the left lower limb. The biopsy showed intense inflammatory infiltrate in the papillary dermis with a predominance of lymphocytes, and medium-caliber vessels surrounded by mononuclear infiltrates in the deep reticular dermis.
View Article and Find Full Text PDF[Multimodal imaging in atypical choroidal nevus].
Pan Afr Med J
February 2021
Service d'Ophtalmologie, Centre Hospitalier Universitaire Farhat Hached de Sousse, Sousse, Tunisie.
Choroidal nevi are frequent, asymptomatic, usually easy-to-diagnose lesions. They can cause macular syndrome in patients with choridal degeneration or neovascularization. In doubtful cases, the combination of different diagnostic means, such as clinical examination, ultrasound, fluorescein angiography and indocyanine green (ICG) can help to correct the diagnosis.
View Article and Find Full Text PDFIdentification of a ERCC5 c.2333T>C (L778P) Variant in Two Tunisian Siblings With Mild Xeroderma Pigmentosum Phenotype.
Front Genet
February 2019
Laboratoire de Génomique Biomédicale et Oncogénétique, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder due to a defect in the nucleotide excision repair (NER) DNA repair pathway, characterized by severe sunburn development of freckles, premature skin aging, and susceptibility to develop cancers at an average age of eight. XP is an example of accelerated photo-aging. It is a genetically and clinically heterogeneous disease.
View Article and Find Full Text PDFAmelanotic melanoma: a unique case study and review of the literature.
BMJ Case Rep
March 2018
Santa Barbara Skin Institute, Santa Barbara, California, USA.
Amelanotic melanoma (AM) is a rare form of melanoma which lacks visible pigment. Due to the achromic manifestation of this atypical cutaneous malignancy, it has been difficult to establish clinical criteria for diagnosis. Thus, AM often progresses into an invasive disease due to delayed diagnosis.
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