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Article Synopsis
  • Botulinum toxin type A is a primary treatment for post-stroke spasticity, specifically targeting nerve endings with minimal impact outside the injection area.
  • Concerns about adverse reactions from toxin diffusion influence how doctors choose to manage spasticity in patients.
  • Key factors affecting diffusion and spread include the dose, dilution, injection volume, along with needle gauge and injection speed, and these should be assessed based on individual patient needs and treatment goals.
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Relationship between reticulospinal system sensitization and proprioceptive pathways in the development of dynamic spasticity (ReProDS) post-spinal cord injury: protocol for a prospective, observational cohort study.

BMC Neurol

November 2024

Department of Neurology and Neurological Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.

Background: Dynamic spasticity (DS) is a common complication post-spinal cord injury (SCI), marked by intermittent increases in muscle tone during postural transitions or movement. Despite its prevalence, high-quality research on DS incidence, risk factors, and underlying mechanisms in SCI patients remains limited. With the growing application of spinal cord stimulation (SCS) for spasticity control, the role of proprioception in DS development has garnered attention.

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Unlabelled: Bronchiolitis is one of the main reasons for the hospitalization of young children. Based on updated recommendations, only supportive therapy is recommended for treatment. In Poland, many children that are hospitalized with bronchiolitis undergo a treatment that is not supported by current research.

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Article Synopsis
  • Post stroke elbow spasticity (PSES) affects over one-third of stroke survivors, significantly hindering their recovery and quality of life, with existing treatments showing limited effectiveness.
  • * The study will enroll 297 participants, randomly assigning them to receive either standard care, TENS, or SHAPES (a new adaptive electrical stimulation method) over six weeks, with various outcome measures assessed at multiple intervals.
  • * The findings from the SHAPES trial aim to determine if this low-cost, self-administered intervention is more effective than traditional methods, potentially leading to widespread use in the NHS for stroke recovery.
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Feasibility of Adjunct Therapy with a Robotic Hand Orthosis after Botulinum Toxin Injections in Persons with Spasticity: A Pilot Study.

Toxins (Basel)

August 2024

Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Gloriastrasse 37/39, 8092 Zurich, Switzerland.

Article Synopsis
  • Upper-limb spasticity commonly occurs after central nervous system lesions and is often treated with botulinum neurotoxin type A (BoNT-A) injections to improve muscle function.
  • This study examined the use of a robotic hand orthosis (RELab tenoexo) combined with a mobile app as a therapy option after BoNT-A injections in chronic spastic patients.
  • Results indicated that after BoNT-A treatment, muscle tone decreased significantly, and most participants showed functional improvements with the robotic therapy, suggesting it could be a beneficial adjunct to traditional treatments.
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