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Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2).
Biochem J
March 2025
Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Quinone reductase 2 (NQO2) is a FAD-linked enzyme that cannot use the common reducing cofactors, NADH and NADPH, for efficient catalysis. This is unusual for an oxidoreductase, particularly since it is a member of a large family of enzymes that all use NAD(P)H efficiently to catalyse the two-electron reduction in quinones and other electrophiles. The inability of NQO2 to use NAD(P)H efficiently raises questions about its cellular function: it remains unclear whether the main cellular role of NQO2 is the catalytic reduction in quinones or whether it is a pseudo-enzyme with other roles such as cell signalling.
View Article and Find Full Text PDFPrevalence, microbiology, and outcome of peritonitis in peritoneal dialysis patients in vietnam: a multicenter study.
BMC Nephrol
March 2025
Department of Dialysis, Cu Chi General Hospital, 09 Nguyen Van Hoai, Bau Tre 2, Tan An Hoi, Cu Chi, Họ, Chi Minh City, Vietnam.
Background: Chronic kidney disease (CKD) is a substantial contributor to global mortality, requiring interventions like kidney transplantation and dialysis. Peritoneal dialysis (PD) has emerged as an effective dialytic modality despite the susceptibility to peritonitis. The study aimed to determine the prevalence of peritonitis among PD patients, elucidating pivotal factors affecting its occurrence, causative bacterial agents, and treatment outcomes (mortality rates, removal of the Tenckhoff catheter, and switch to hemodialysis).
View Article and Find Full Text PDFComplete genome sequence of fig leaf mottle-associated virus 2.
Arch Virol
March 2025
Department of Genetics, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa.
The complete genome sequence of fig leaf mottle-associated virus 2 (FLMaV2), a positive-sense single-stranded RNA virus with a genome length of 16,925 nucleotides, was determined via RT-PCR and rapid amplification of cDNA ends (RACE). Its genome organization resembles those of little cherry virus 2 (LChV2) and yam asymptomatic virus 1 (YaV1), both of which are currently classified as members of the genus Ampelovirus but differ from typical ampeloviruses. Phylogenetic analysis based on amino acid sequences of the RNA-dependent RNA polymerase and coat protein of members of the family Closteroviridae showed that FLMaV2 clustered with LChV2 and YaV1.
View Article and Find Full Text PDFMetastatic olfactory neuroblastoma with unusual solitary metastasis to femur: a case report and literature review.
World J Surg Oncol
March 2025
Department of Orthopedic Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: Olfactory neuroblastoma (ONB) is a rare malignancy that develops in the nasal cavity, with appendicular skeletal metastases being exceptionally uncommon. We report the case of a middle-aged male with ONB, presenting with an unusual biopsy-confirmed solitary metastasis to the left proximal femur.
Case Presentation: A 33-year-old male was previously diagnosed with olfactory neuroblastoma in the skull base after initial clinical presentation with progressive left-sided nasal obstruction for six months.
Identifying the interactions conferring functional mechanical rigidity on RNase-resistant RNA from Zika virus.
Proc Natl Acad Sci U S A
March 2025
Department of Physics, University of Alberta, Edmonton, AB T6G2E1, Canada.
Some viruses counter host-cell efforts to digest invading viral RNA by using special structures resistant to host RNases, known as exoribonuclease-resistant RNAs (xrRNAs). xrRNAs typically form an unusual fold with the 5'-end threaded through a ring consisting of a multihelix junction closed by a pseudoknot. By using single-molecule force spectroscopy (SMFS), we previously showed that a Zika virus xrRNA is extremely rigid mechanically, withstanding very high forces, and that this mechanical resistance-not simply the knot-like fold topology-is essential for RNase resistance.
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