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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan.
J Pharm Biomed Anal
November 2023
Novosibirsk State University, Pirogov St., 2, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of Russian Academy of Sciences, Lavrent'ev ave., 8, Novosibirsk 630090, Russia. Electronic address:
We have previously shown that the Tdp1 inhibitor, enamine derivative of usnic acid, the agent OL9-116, enhances the antitumor activity of topotecan. In the present study, we developed and validated LC-MS/MS method for the quantification of OL9-116 in mouse whole blood and studied pharmacokinetics of the agent. The substance OL9-116 was shown to be stable in the whole blood in vitro.
View Article and Find Full Text PDFAntioxidant Activity of Usnic Acid Compound from Methanol Extract of Lichen Usnea sp.
J Oleo Sci
February 2023
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Halu Oleo.
Lichen Usnea sp. is one of the sources of natural bioactive compounds which are currently being developed as medicinal ingredients. The purpose of this study was the isolation and identification of secondary metabolites from methanol extract, toxicity test and antioxidant activity of Usnea sp.
View Article and Find Full Text PDFNovel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichens.
Phytochemistry
August 2022
Faculty of Pharmaceutical Sciences, University of Iceland, 107, Reykjavik, Iceland.
Usnic acid is an antibiotic metabolite produced by a wide variety of lichenized fungal lineages. The enantiomers of usnic acid have been shown to display contrasting bioactivities, and hence it is important to determine their spatial distribution, amounts and enantiomeric ratios in lichens to understand their roles in nature and grasp their pharmaceutical potential. The overall aim of the study was to characterise the spatial distribution of the predominant usnic acid enantiomer in lichens by combining spatial imaging and chiral chromatography.
View Article and Find Full Text PDFPotential of Usnic Acid Compound from Lichen Genus Usnea sp. as Antidiabetic Agents.
J Oleo Sci
February 2022
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Halu Oleo.
Lichen Usnea sp. is potential as a new natural medicine. This study report isolation of secondary metabolites from lichen Usnea sp.
View Article and Find Full Text PDFA Review of Anti-Cancer and Related Properties of Lichen-Extracts and Metabolites.
Anticancer Agents Med Chem
March 2022
Department of Biotechnology, Kumaun University Campus, Bhimtal, Uttarakhand 263136, India.
Background: Lichens are a composite consortium of a fungus and an alga. The symbiotic organisms are naturally equipped with distinct characteristics as compared to constituting organisms separately. Lichens, due to their peculiar anatomy and physiology, are the reservoir of more than 600 unique secondary metabolites, also known as 'lichen substances'.
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