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[Pretibial myxedema after Graves' disease: A differential diagnosis of lymphedema].
Rev Med Interne
December 2023
Unité de lymphologie, site constitutif du centre national de référence des lymphœdèmes primaires, hôpital Cognacq-Jay, 15, rue Eugène-Millon, 75015 Paris, France. Electronic address:
Article Synopsis
- Pretibial myxedema is an uncommon symptom of Graves' disease that can resemble lower limb lymphedema, complicating diagnosis.* -
- The study includes three cases of pretibial myxedema in patients with a history of Graves' disease, where misdiagnosis of lymphedema was suspected due to specific leg symptoms.* -
- Proper diagnosis involves evaluating the patient's medical history, particularly regarding Graves' disease, and addressing lifestyle factors like smoking that could worsen the condition.*
Hypertrophic genital herpes in an HIV-infected female patient: Imiquimod as an alternative treatment.
Int J Infect Dis
June 2020
Infectious Diseases Post-Graduate Program, Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil. Electronic address:
Herpes Simplex Virus (HSV) is the leading cause of genital ulcers worldwide. In Human Immunodeficiency Virus (HIV) co-infected individuals, rare hypertrophic pseudo-tumoral forms have been described as simulating squamous cell carcinoma or other viral infections such as those caused by Varicella zoster, Molluscum contagiosum and HPV induced lesions. Here, we report a case of hypertrophic genital herpes in an HIV-infected patient effectively treated with surgery and topical 5% imiquimod after the recurrence of lesions.
View Article and Find Full Text PDFPancreatic and biliary tract involvement in IgG4-related disease.
Presse Med
April 2020
Pancreatology unit, Inserm, UMR 1149, pancreatic rare diseases (PaRaDis), centre de reference de maladies rares, Beaujon hospital, 100, boulevard Gal-Leclerc, 92110 Clichy, France.
The diagnosis and treatment of pancreatic and biliary tract involvement in IgG4 disease can be challenging for physicians. A French series shows that the pancreas is the most frequently involved organ in systemic IgG4 disease. Pancreatitis may be found in more than 50% of patients with IgG4 disease and the biliary tract is involved in one third.
View Article and Find Full Text PDFTardive Reactivation of Progressive Multiple Sclerosis During Treatment with Biotin.
Neurol Ther
June 2020
Department of Neurology, Reference Centre for Adult Leukodystrophies, Montpellier University Hospital, Montpellier, France, Montpellier, France.
Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system, causing neurological disability in young adults. A growing understanding of its immunopathogenesis has led to an expanding array of therapies. Notable new advances in disease-modifying therapies for relapsing forms of multiple sclerosis that are based on anti-inflammatory activity have recently been developed.
View Article and Find Full Text PDF[Cryopyrin-associated periodic syndromes].
Rev Med Interne
April 2018
Filière maladies rares FAI2R, 75000 Paris, France; Assistance publique-Hôpitaux de Paris, 75000 Paris, France; Service de médecine interne, centre de référence national maladies rares pour les maladies auto-inflammatoires et l'amylose (CEREMAIA), hôpital Tenon, université Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France.
Cryopyrin-associated periodic syndromes (CAPS) are linked to one single gene mutations, however they are associated with 3 syndromes, which are, from the mildest to the most severe phenotype familial cold urticaria, Muckle-Wells syndrome and chronic, infantile, neurologic, cutaneous, articular (CINCA) syndrome also called neonatal-onset multisystem inflammatory disease (NOMID). Autosomic dominant inheritance is present in most cases but in CINCA/NOMID syndrome where neomutations are more common. Mutations in the gene encoding cryopyrin, NLRP3, are associated with deregulation of caspase-1 activity, excessive interleukin-1 production and an autoinflammatory syndrome, which in familial cold urticaria and Muckle-Wells syndrome may be triggered or worsened by exposure to coldness.
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