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Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.
Nat Neurosci
January 2025
Department of Physiology, Seoul National University College of Medicine, Seoul, Korea.
The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown. Here, we show that in mice, cutaneous noxious electrical stimuli induced noradrenaline (NA) release from locus coeruleus (LC) terminals in the cerebellar cortex. Bergmann glia (BG) accumulated these LC-NA signals by increasing intracellular calcium in an integrative manner ('flares').
View Article and Find Full Text PDFEnigma of Sustainable CO Conversion to Renewable Fuels and Chemicals Through Photocatalysis, Electrocatalysis, and Photoelectrocatalysis: Design Strategies and Atomic Level Insights.
Small
January 2025
Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Growing global population, escalating energy consumption, and climate change threaten future energy security. Fossil fuel combustion, primarily coal, oil, and natural gas, exacerbates the greenhouse effect driving global warming through CO emissions. To address such issues, research is focused on converting CO into valuable fuels and chemicals, which aims to reduce noxious CO and simultaneously bridge the gap between energy demands and sustainable supply.
View Article and Find Full Text PDFSensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation.
Front Mol Neurosci
December 2024
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.
Introduction: The prostate is densely innervated like many visceral organs and glands. However, studies to date have focused on sympathetic and parasympathetic nerves and little attention has been given to the presence or function of sensory nerves in the prostate. Recent studies have highlighted a role for sensory nerves beyond perception of noxious stimuli, as anterograde release of neuropeptides from sensory nerves can affect vascular tone and local immune responses.
View Article and Find Full Text PDFCharacterization of the anesthetic effects of dexmedetomidine-vatinoxan-ketamine combinations in cats.
Vet Anaesth Analg
December 2024
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Objective: To characterize the anesthetic effects of dexmedetomidine, vatinoxan and ketamine combinations in cats.
Study Design: Randomized crossover experimental study.
Animals: A group of seven healthy male neutered cats, with body mass 5.
In Obesity, Esophagogastric Junction Fat Impairs Esophageal Barrier Function and Dilates Intercellular Spaces via HIF-2α.
Gastroenterology
December 2024
Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX. Electronic address:
Background & Aims: Dilated intercellular space (DIS) in esophageal epithelium, a sign of impaired barrier function, is a characteristic finding of GERD that also is found in obese patients without GERD. We have explored molecular mechanisms whereby adipose tissue products might impair esophageal barrier integrity.
Methods: We established cultures of visceral fat obtained during foregut surgery from obese and non-obese patients.
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