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In vitro antiplasmodial activity and chemical composition of Combretum aculeatum, a medicinal plant from Niger.
Chem Biodivers
January 2025
Universite de Strasbourg, UMR 7200 Laboratoire d'Innovation Thérapeutique, 74 route du Rhin - CS 60024 - 67401 Illkirch Cédex - France, 67400, Illkirch-Graffenstaden, BELGIUM.
Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria-related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
View Article and Find Full Text PDFMetabolomics integrated genomics approach: Understanding multidrug resistance phenotype in MCF-7 breast cancer cells exposed to doxorubicin and ABCA1/EGFR/PI3k/PTEN crosstalk.
Toxicol Rep
June 2025
National Research Center, Therapeutic Chemistry Department, Al Bohouth Street, Egypt.
Resistance of cancer cells, especially breast cancer, to therapeutic medicines represents a major clinical obstacle that impedes the stages of treatment. Carcinoma cells that acquire resistance to therapeutic drugs can reprogram their own metabolic processes as a way to overcome the effectiveness of treatment and continue their reproduction processes. Despite the recent developments in medical research in the field of drug resistance, which showed some explanations for this phenomenon, the real explanation, along with the ability to precisely predict the possibility of its occurrence in breast cancer cells, still necessitates a deep consideration of the dynamics of the tumor's response to treatment.
View Article and Find Full Text PDFReview of carbonaceous nanoparticles for antibacterial uses in various dental infections.
Nanotoxicology
January 2025
Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
The mouth cavity is the second most complex microbial community in the human body. It is composed of bacteria, viruses, fungi, and protozoa. An imbalance in the oral microbiota may lead to various conditions, including caries, soft tissue infections, periodontitis, root canal infections, peri-implantitis (PI), pulpitis, candidiasis, and denture stomatitis.
View Article and Find Full Text PDF[Full-Endoscopic Spine Surgery for Lumbar Lesions; Basics and Applications].
No Shinkei Geka
January 2025
Department of Neurosurgery, Yao Tokushukai General Hospital.
Full endoscopic spine surgery is a technique to perform hernia extraction using a single-hole-type endoscope with a coaxial operation system of a sheath, endoscope, and surgical instrument in reflux water. In the lumbar region, the ventral side of the dura mater can be directly approached via the lateral route. Not only is the skin incision small, but damage to muscle tissue is also minimal, which is why it is a minimally invasive surgery.
View Article and Find Full Text PDFElectrochemically Driven Selective Olefin Epoxidation by Cobalt-TAML Catalyst.
J Am Chem Soc
January 2025
Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, South Korea.
Epoxides are versatile chemical intermediates that are used in the manufacture of diversified industrial products. For decades, thermochemical conversion has long been employed as the primary synthetic route. However, it has several drawbacks, such as harsh and explosive operating conditions, as well as a significant greenhouse gas emissions problem.
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