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Metabolic rewiring enables ammonium assimilation via a non-canonical fumarate-based pathway.
Microb Biotechnol
March 2024
FG Molecular Microbiology, Institute for Biology, University of Hohenheim, Stuttgart, Germany.
Glutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT). The glutamate dehydrogenases are devoted to glutamate degradation in vivo.
View Article and Find Full Text PDFComprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Cell Metab
October 2023
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
Article Synopsis
- Stable isotopes help assess metabolism, and the new MS method can identify all isotopomers of aspartate and glutamate using less than 1% of the sample required for NMR.
- This method improves the specificity in distinguishing between metabolic pathways that yield the same count of carbon labels in these amino acids.
- The approach reveals metabolic differences in human tumors and the role of fumarate hydratase deficiency in renal cancers, enhancing in vivo isotope-labeling studies.
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis.
RNA Biol
January 2023
Department of Geriatrics, Gerontology Institute of Anhui Province, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated in various tumour pathological processes. Interestingly, several TCA enzymes exhibit the characteristics of RNA binding properties, and their long non-coding RNA (lncRNA) partners play critical regulatory roles in regulating the function of TCA cycle and tumour progression.
View Article and Find Full Text PDFCombined Metabolome and Transcriptome Analyses Unveil the Molecular Mechanisms of Fruit Acidity Variation in Litchi ( Sonn.).
Int J Mol Sci
January 2023
Institute of Fruit Tree Research, Guangdong Academy of Agricultural Sciences/Key Laboratory of South Subtropical Fruit Biology and Genetic Resource Utilization, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Tropical and Subtropical Fruit Tree Research, Guangzhou 510640, China.
Fruit acidity determines the organoleptic quality and nutritive value of most fruits. In litchi, although the organic acid composition of pulps is known, the molecular mechanisms and genes underlying variation in fruit acidity remain elusive. Herein, developing pulps of two contrasting litchi varieties, Huaizhi (HZ, low-acidity) and Boye_No.
View Article and Find Full Text PDFWild soybean salt tolerance metabolic model: Assessment of storage protein mobilization in cotyledons and C/N balance in the hypocotyl/root axis.
Physiol Plant
January 2023
Institute of Grassland Science, Northeast Normal University, Key Laboratory of Vegetation Ecology, Ministry of Education, Changchun, China.
Salt stress has become one of the main factors limiting crop yield in recent years. The post-germinative growth is most sensitive to salt stress in soybean. In this study, cultivated and wild soybeans were used for an integrated metabonomics and transcriptomics analysis to determine whether wild soybean can resist salt stress by maintaining the mobilization of stored substances in cotyledons and the balance of carbon and nitrogen in the hypocotyl/root axis (HRA).
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