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Health impacts of PM emissions from brake pad wear: A comprehensive study on pulmonary, metabolic, and microbiota alterations.
Toxicology
January 2025
National Human Diseases Animal Model Resource Center, National Center of Technology Innovation for animal model, State Key Laboratory of Respiratory Health and Multimorbidity, NHC Key Laboratory of Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, CAMS & PUMC, Beijing, China. Electronic address:
The environmental impact of harmful particles from tire and brake systems is a growing concern. This study investigated the health impacts of PM emissions from brake pad wear on adult C57BL/6 mice. The mice were exposed to brake pad particles via intratracheal infusion, and various health parameters were assessed.
View Article and Find Full Text PDFComparison of the composition, immunological activity and anti-fatigue effects of different parts in sika deer antler.
Front Pharmacol
December 2024
College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Background: Sika deer (, 1838) antler is a highly esteemed tonic renowned for its abundant assortment of polypeptides, polysaccharides, amino acids, and minerals, and is recognized for its multifarious pharmacological properties. However, limited research has been conducted regarding the variation in composition of deer antlers between the upper and basal sections, as well as their pharmacological effects on immunological activity and anti-fatigue in mice. The objective of this study was to conduct a comprehensive analysis on the appearance, chemical composition, and pharmacological effects of different components within sika deer antlers.
View Article and Find Full Text PDFAcute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics - protective role of succinate.
J Bioenerg Biomembr
December 2024
Laboratory of Experimental Biophysics, Centre for Advanced Technologies, Tashkent, Uzbekistan.
The main therapeutic strategy for the treatment of patients with toxic liver failure is the elimination of the toxic agent in combination with the targeted mitigation of pathological processes that have been initiated due to the toxicant. In the current research we evaluated the strategy of metabolic supplementation to improve mitochondrial bioenergetics during acute liver intoxication. In our study, we have shown that acute CCl-induced intoxication negatively affects Complex I (in the presence of glutamate-malate as energy substrates) based respiration, generation of mitochondrial membrane potential (ΔΨ), mitochondrial NAD(P)H pool and NADH redox index, mitochondrial calcium retention capacity (CRC) and structure and functions of the liver.
View Article and Find Full Text PDFThe metabolic engineering of Escherichia coli for the high-yield production of hypoxanthine.
Microb Cell Fact
November 2024
College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, P. R. China.
Background: Hypoxanthine, prevalent in animals and plants, is used in the production of food additives, nucleoside antiviral drugs, and disease diagnosis. Current biological fermentation methods synthesize quantities insufficient to meet industrial demands. Therefore, this study aimed to develop a strain capable of industrial-scale production of hypoxanthine.
View Article and Find Full Text PDFImpact of sleep problems on the cardiometabolic risks: an integrated epidemiological and metabolomics study.
Diabetol Metab Syndr
November 2024
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Article Synopsis
- The study explored the link between sleep issues, like snoring and sleep apnea, and various cardiometabolic risks, including obesity and hypertension, using a mix of observational data and genetic analysis.
- It found significant associations between sleep problems and increased risks for conditions like obesity and type 2 diabetes, confirmed through Mendelian randomization (MR) studies.
- Additionally, altered metabolism was observed in zebrafish models, highlighting potential metabolic pathways associated with sleep disorders and their impact on cardiometabolic health.
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