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Penthrox (Methoxyflurane) as an Analgesic for Removal of Circular External Fixators and Minor Procedures during the COVID-19 Pandemic.
Strategies Trauma Limb Reconstr
January 2023
Department of Trauma and Reconstruction, Alder Hey Children's Hospital, Liverpool, United Kingdom.
Introduction: Methoxyflurane has excellent analgesic properties and is approved for use in the United Kingdom and Ireland since 2015. It is currently used in emergency departments for analgesia during fracture reductions. During the COVID-19 pandemic, with theatre access severely restricted, Penthrox® had the potential to provide adequate pain relief to aid frame and wire removal in the clinic setting.
View Article and Find Full Text PDFGenetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity.
J Neurogenet
January 2012
Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892-3736, USA.
Mutations that influence the sensitivity of an organism to a volatile general anesthetic can be divided into two classes. In one, sensitivity to all other volatile agents is affected to a similar degree. Although this class may contain mutations of interest for understanding anesthesia, it is also likely to contain mutations that merely alter general health.
View Article and Find Full Text PDF[Nephrotoxicity and fluoride from the viewpoint of the nephrologist].
Anaesthesist
February 1996
Medizinische Klinik I, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Fluoride released from methoxyflurane (MOF) during its hepatic and extrahepatic metabolism has been regarded as the major culprit responsible for MOF-induced nephrotoxicity. In the isolated, perfused rat kidney model, admixture of 1500 mumol/l fluoride to the perfusate resulted in tubular and glomerular damage with concomitant anuria. Fluoride administration in Fischer 344 rats in vivo elicited a renal diabetes insipidus-like syndrome that had also been observed in patients after MOF anaesthesia.
View Article and Find Full Text PDFThe effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptor.
Br J Pharmacol
December 1995
Biophysics Section, Blackett Laboratory, Imperial College of Science, Technology and Medicine, South Kensington, London.
1. Completely isolated identified neurones from the right parietal ganglion of the pond snail Lymnaea stagnalis were investigated under two-electrode voltage clamp. Neuronal nicotinic acetylcholine receptor (AChR) currents were studied at low acetylcholine concentrations (< or = 200 nM).
View Article and Find Full Text PDFLack of residual effects of diethyl ether, methoxyflurane, and sodium pentobarbital on lidocaine metabolism in a single-pass isolated rat liver perfusion system.
Drug Metab Dispos
April 1995
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
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