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Elucidating the Biological Potential and DNA Protective Activities of Astragalus tokatensis Fisch: GC-MS and LC-HRMS-based Characterization and Molecular Docking Studies.
Chem Biodivers
January 2025
Tokat Gaziosmanpasa University Faculty of Arts and Sciences: Tokat Gaziosmanpasa Universitesi Fen Edebiyat Fakultesi, Biology, Tokat, Tokat, TURKEY.
Astragalus tokatensis is a local endemic species and no study exists on this species. In this study, hexane, dichloromethane, methanol and water extracts were obtained from the parts of root, leaf and flower of A. tokatensis.
View Article and Find Full Text PDFPeptidomics and molecular dynamics on bioactive peptides produced and characterized from the fermented whey of "Panchali" sheep of West India.
Food Chem
March 2025
Department of Dairy Microbiology, SMC College of Dairy Science, Kamdhenu University, Anand 388110, Gujarat, India. Electronic address:
The study assessed the peptide production by using potent Lactiplantibacillus plantarum KGL3A (MG722814) culture to ferment the sheep milk for evaluation of α-glucosidase inhibition, ACE inhibition, α-amylase inhibition, & inhibiting lipase activities. The maximal ACE inhibitory, α-amylase, α-glucosidase, & lipase inhibiting actions were 71.69 %, 71.
View Article and Find Full Text PDFVenom characterization of Venezuelan scorpion Tityus caripitensis.
Toxicon
December 2024
Fundación Instituto de Estudios Avanzados (IDEA), Carretera Nacional Hoyo de la Puerta, Valle de Sartenejas, Baruta, Venezuela.
Article Synopsis
- Tityus caripitensis is an endemic scorpion from northeastern Venezuela, causing sting incidents, and this study is the first to explore its venom's biological, biochemical, and electrophysiological properties.
- The venom exhibits toxicity to mice with an LD50 of 20.2 μg/gr, and SDS-PAGE analysis identified 7 protein fractions, including potential neurotoxins in the 6-8 kDa range.
- The venom caused significant changes in blood chemistry and affected sodium and potassium ion channels, and while it is less toxic than Tityus discrepans, they share molecular similarities that are important for antivenom treatment.
Isolated IgG4-related Infundibulo-hypophysitis.
JCEM Case Rep
October 2024
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226 USA.
A 72-year-old man presented with several months of weakness, poor appetite, and depressed moods. Laboratory tests indicated central hypocortisolism, hypothyroidism and hypogonadism, and mild hyperprolactinemia. Imaging indicated a homogenously enhancing solid suprasellar mass inseparable from the hypothalamus and contiguous with a thickened proximal infundibulum.
View Article and Find Full Text PDFPhysicochemical properties, antioxidant and antidiabetic activities of different hydrolysates of goat milk protein.
J Dairy Sci
December 2024
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, Shaanxi, China. Electronic address:
There is growing interest in the origin, preparation, and application of bioactive peptides. This study investigated the effect of 6 enzymes on the structural, physicochemical properties, antioxidant activities, and antidiabetic potential of defatted fresh goat milk. Structural and functional changes resulting from enzymatic hydrolysis were assessed using gel electrophoresis, laser particle size analysis, multi-spectroscopy, and evaluations of foaming and emulsification properties.
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