Some children with cerebral palsy attend the ten-form general polytechnical school. To this end, several prerequisites have to be fulfilled and other essential arrangements to be developed in cooperation with specially trained teachers. The learning conditions have to be fitted to the improving abilities of children during the educational process. Factors of influence and cooperation modes are discussed.
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Front Bioeng Biotechnol
January 2025
Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background: Currently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).
View Article and Find Full Text PDFData Brief
February 2025
Technological University Dublin, Faculty of Engineering and Built Environment, School of Surveying and Construction Innovation, Room 334.1, Bolton Street, D01 K822, Dublin, Ireland.
The dataset offers a comprehensive information to analyse cities and neighbourhood that are potentially unsafe for women, this information has been collected for four cities: Toluca (Mexico), Valencia (Spain), Dublin (Ireland) and San Francisco (USA). The collection includes quantitative and qualitative variables obtained and processed from open data, georeferenced publications from a social media platform, and points located through participatory mapping sessions. The data is structured in raw format, organized by country and city, and categorized according to the data source used while processing, which allows unrestricted access with most data analysis software and it does not depend on specific licenses.
View Article and Find Full Text PDFComb Chem High Throughput Screen
January 2025
Jiangsu College of Tourism, Yangzhou 225000, P.R. China.
Aims: Organic thiocyanates are important pharmaceutical intermediates. This study aimed to develop a selective and efficient approach for synthesizing organic thiocyanates.
Methods: Under mild reaction conditions, an array of alkenes, KSCN, and diaryliodonium salts are considered good substrates, providing various aryl-substituted alkylthiocyanates with modest to excellent yield.
Sci Rep
January 2025
College of Big Data Statistics, Guizhou University of Finance and Economics, Guiyang, 550025, China.
Deep learning has achieved significant success in the field of defect detection; however, challenges remain in detecting small-sized, densely packed parts under complex working conditions, including occlusion and unstable lighting conditions. This paper introduces YOLOv8-n as the core network to propose VEE-YOLO, a robust and high-performance defect detection model. Firstly, GSConv was introduced to enhance feature extraction in depthwise separable convolution and establish the VOVGSCSP module, emphasizing feature reusability for more effective feature engineering.
View Article and Find Full Text PDFDrug Discov Today
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China. Electronic address:
Protein-protein interactions (PPIs) are fundamental to a variety of biological processes, but targeting them with small molecules is challenging because of their large and complex interaction interfaces. However, peptides have emerged as highly promising modulators of PPIs, because they can bind to protein surfaces with high affinity and specificity. Nonetheless, computational peptide design remains difficult, hindered by the intrinsic flexibility of peptides and the substantial computational resources required.
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