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Enhanced Transepithelial Riboflavin Delivery Across the Cornea Using Magnetic Nanocarriers.
J Ocul Pharmacol Ther
January 2025
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara Medipol University, Ankara, Turkey.
Keratoconus is a progressive corneal ectasia characterized by irregular astigmatism, leading to corneal scarring and decreased vision. Corneal cross-linking (CXL) is the standard treatment to halt disease progression, but its effectiveness in transepithelial (epithelium-on, epi-on) approaches is limited by the low permeability of the corneal epithelium to riboflavin (Rb). This study aimed to enhance transepithelial Rb penetration in bovine corneas using Rb-modified tannic acid-coated superparamagnetic iron oxide nanoparticles (Rb-TA-SPIONs) under an external magnetic field.
View Article and Find Full Text PDFScreening of Aluminum-Based MOFs for Effective In Situ Immobilization of Biomolecules.
Inorg Chem
January 2025
Institut Lavoisier de Versailles, UMR CNRS 8180, UVSQ, Université Paris-Saclay, 78035 Versailles, France.
An effective approach for the immobilization and protection of biological entities is their encapsulation via the in situ synthesis of metal-organic frameworks (MOFs). To ensure the preservation of the bioentities, mild synthetic conditions, including aqueous media and ambient conditions (temperature and pressure), are preferred. In this study, we investigated the synthesis of various aluminum polycarboxylate-based MOFs, including the fumarate, terephthalate, amino-terephthalate, and muconate forms of MIL-53(Al), as well as the MIL-110 and MIL-160 MOF types.
View Article and Find Full Text PDF(pollen beetle) gastrointestinal disease experimentally reproduced in sheep.
Vet Pathol
January 2025
University of California, Davis, San Bernardino, CA.
Intoxication of sheep and cattle by recently occurred in Uruguay and Argentina in association with severe drought. Although the disease was experimentally reproduced in sheep in the 1970s, there is limited information on clinical and pathologic findings of sheep experimentally intoxicated by this beetle. Here, we described the clinical, gross, and microscopic findings in 3 sheep orally dosed with (treatment group, TG) and in 2 control sheep (control group, CG) dosed with distilled water.
View Article and Find Full Text PDFEffects of UV-B light exposure during automatic milking on vitamin D levels in Holstein Friesian cows.
Front Vet Sci
January 2025
Clinic for Reproduction and Large Animals-Section for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Vitamin D is essential for cattle and can be synthesized in the skin under ultraviolet irradiation. This study investigated the effects of narrow-band UV-B irradiation during automatic milking on blood vitamin D concentration and the influence of hair and black skin areas on cutaneous vitamin D synthesis in Holstein Friesian cows. Fifty-one cows were stratified by milk yield, days after calving, and percentage of black skin, then divided into three groups: shaved and irradiated (80 J/m), unshaved and irradiated (129-305 J/m), and a control group.
View Article and Find Full Text PDFSustainable utilization of bovine adipose tissue derivatives as robust antimicrobial agents against Methicillin-resistant Staphylococcus aureus.
BMC Microbiol
January 2025
Department of Internal Medicine and Infectious Diseases (Infectious Diseases), Faulty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: The excessive use of antibiotics is a major contributor to the global issue of antimicrobial resistance (AMR), a significant threat to human and animal health. Hence, assessing new strategies for managing Multi-Drug Resistant (MDR) microorganisms is vital. In this study, the use of mechanically isolated mature adipose cells (MIMACs) and their lysate (Adipolysate) as a new sustainable antimicrobial agent was assessed against Methicillin-resistant Staphylococcus aureus (MRSA).
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