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Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction.
Elife
October 2024
Sorbonne Université, CNRS UMR7622, INSERM U1156, Institut de Biologie Paris Seine (IBPS) - Developmental Biology Unit, Paris, France.
Cilia defects lead to scoliosis in zebrafish, but the underlying pathogenic mechanisms are poorly understood and may diverge depending on the mutated gene. Here, we dissected the mechanisms of scoliosis onset in a zebrafish mutant for the gene encoding a ciliary transition zone protein. mutant fish developed scoliosis with near-total penetrance but asynchronous onset in juveniles.
View Article and Find Full Text PDFEmergence of time persistence in a data-driven neural network model.
Elife
March 2023
Laboratory of Physics of the Ecole Normale Supérieure, CNRS UMR 8023 & PSL Research, Sorbonne Université, Université de Paris, Paris, France.
Establishing accurate as well as interpretable models of network activity is an open challenge in systems neuroscience. Here, we infer an energy-based model of the anterior rhombencephalic turning region (ARTR), a circuit that controls zebrafish swimming statistics, using functional recordings of the spontaneous activity of hundreds of neurons. Although our model is trained to reproduce the low-order statistics of the network activity at short time scales, its simulated dynamics quantitatively captures the slowly alternating activity of the ARTR.
View Article and Find Full Text PDFMammalian NREM and REM sleep: Why, when and how.
Neurosci Biobehav Rev
March 2023
Laboratori de Fisiologia del son i els ritmes biologics. Universitat de les Illes Balears, Ctra. Valldemossa Km 7.5, 07122 Palma de Mallorca (España); IDISBA. Institut d'Investigació Sanitaria de les Illes Balears; IUNICS Institut Universitari d'Investigació en Ciències de la Salut. Electronic address:
This report proposes that fish use the spinal-rhombencephalic regions of their brain to support their activities while awake. Instead, the brainstem-diencephalic regions support the wakefulness in amphibians and reptiles. Lastly, mammals developed the telencephalic cortex to attain the highest degree of wakefulness, the cortical wakefulness.
View Article and Find Full Text PDFCLIPPERS, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A challenge in neurological practice, clinical landmarks (Review).
Exp Ther Med
October 2021
Department of Neurology, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a relatively newly discovered and characterized condition affecting the central nervous system (CNS) that involves the brainstem almost ubiquitously and that focuses primarily on the pons. Characteristically, CLIPPERS represents a combination of clinical symptoms related to the pathology of the brainstem in particular and has a characteristic appearance on magnetic resonance imaging (MRI), with punctate and curvilinear gadolinium enhancement 'peppering' the pons. The lesions can be viewed via neuroimaging with a predominance in the pons and adjacent rhombencephalic structures, such as the cerebellar peduncles, cerebellum, medulla, and middle brain.
View Article and Find Full Text PDFDescending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.
J Neurosci
October 2020
Department of Neuroscience, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Meso-diencephalic dopaminergic neurons are known to modulate locomotor behaviors through their ascending projections to the basal ganglia, which in turn project to the mesencephalic locomotor region, known to control locomotion in vertebrates. In addition to their ascending projections, dopaminergic neurons were found to increase locomotor movements through direct descending projections to the mesencephalic locomotor region and spinal cord. Intriguingly, fibers expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, were also observed around reticulospinal neurons of lampreys.
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