The leiomyoblastoma of the stomach has emerged as a separate entity different from the well known benign and malignant gastric tumours of smooth muscle origin. The histologic picture is very typical but has puzzled many pathologists in the past. It is important to consider the possibility of this tumour at operation because it will influence the type of operation to be carried out. Even with seeminly hopeless spread a curative resection is often possible. Per-operative frozen section diagnosis is imperative. Enucleation alone is inadequate. Wide local excision without removal of the regional lymph nodes is often sufficient. More radical operations have no apparent effect on survival. A total gastrectomy is only indicated in cases of multiple localisations or recurrences. Primary and secondary excision of metastases should be considered. Prognosis is relatively good and is best evaluated by a combination of clinical and histologic criteria.
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Gastrointestinal stromal tumors in fine-needle aspiration biopsies.
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Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
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Diagn Cytopathol
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Department of Laboratory Medicine, Robert J Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Background: The diagnosis of spindle cell neoplasms (SCN) of the upper gastrointestinal (GI) tract, hepatobiliary tract, and pancreas detected by fine needle aspiration (FNA) is challenging. We describe a single-center experience of these samples with follow-up data and characterization of the morphologic findings.
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PDGFRA Immunohistochemistry Predicts PDGFRA Mutations in Gastrointestinal Stromal Tumors.
Am J Surg Pathol
January 2022
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
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Department of Pathology, "Colentina" Clinical Hospital, Bucharest, Romania;
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- Gastrointestinal stromal tumors (GISTs) are controversial among pathologists regarding their origin, classification, and potential for malignancy.
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A rare case with synchronous gastric gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and uterine leiomyoma.
World J Surg Oncol
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Department of General and Hepato-pancreatic Surgery, University Hospital "Alexandrovska"-Sofia, 1 Georgi Sofiiski Str, 1431, Sofia, Bulgaria.
Background: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers.
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