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Ageing is a major risk factor for neurodegenerative diseases like Alzheimer's disease (AD). Microglia, as the principal innate immune cells within the brain, exert homeostatic and active immunological defense functions throughout human lifespan. The age-related dysfunction of microglia is currently recognized as a pivotal trigger for brain diseases associated with aging.
View Article and Find Full Text PDFDifferential infection dynamics in mononuclear and polymorphonuclear cells during Salmonella Typhimurium infection and in vitro exposure to diazoxon.
Microb Pathog
January 2025
Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA)-Nayarit, Universidad Autónoma de Nayarit, Tepic 63173, Nayarit, México; Licenciatura en Biomedicina Ambiental Traslacional, Universidad Autónoma de Nayarit, Circuito C. Ney M. González, Ciudad del conocimiento, 63173 Tepic, Nay. México.
S. Typhimurium bacteria cause one of the most recurrent gastrointestinal diseases worldwide. This bacterium can settle in the gastrointestinal tract and internalize into different cellular strains, causing the formation of cellular reservoirs that subsequently lead to systemic dissemination.
View Article and Find Full Text PDFPerformance of Extracellular Vesicles From () for Serological Diagnosis of Human and Canine Visceral Leishmaniasis.
J Parasitol Res
January 2025
Parasitology and Mycology Center, Adolfo Lutz Institute, Sao Paulo, Brazil.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
View Article and Find Full Text PDFIron improves the antiviral activity of NK cells.
Front Immunol
January 2025
Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Natural killer (NK) cells are innate immune cells that play a crucial role as a first line of defense against viral infections and tumor development. Iron is an essential nutrient for immune cells, but it can also pose biochemical risks such as the production of reactive oxygen species. The importance of iron for the NK cell function has gained increasing recognition.
View Article and Find Full Text PDFEvaluation of antihistamine-refractory chronic urticaria patients who used biological agent treatment in terms of cardiovascular risk.
Postepy Dermatol Alergol
December 2024
Department of Allergy and Immunology, Tepecik Education and Research Hospital, İzmir, Turkey.
Introduction: The idea that chronic inflammatory processes may play a role in the etiopathogenesis of both treatment - refractory chronic spontaneous urticaria and cardiovascular diseases is an important research topic.
Aim: Within the scope of this research, we aimed to elucidate a new perspective on the follow-up of chronic urticaria patients by evaluating the 10-year cardiovascular risk and metabolic syndrome in resistant chronic spontaneous urticaria patients who were unresponsive to maximum antihistamine treatment.
Material And Methods: A total of 170 individuals who applied to our institution's Health Science University, Tepecik Education and Research Hospital, allergy and immunology outpatient clinic have been analysed in this retrospective case-control study.
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