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Purpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
MaxEnt-Based Predictions of Suitable Potential Distribution of Under Current and Future Climate Change.
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January 2025
Key Laboratory of Efficient Forage Production Mode, Ministry of Agriculture and Rural Affair, College of Grassland Science, Shanxi Agricultural University, Jinzhong 030801, China.
Grassland degradation is a serious ecological issue in the farming-pastoral ecotone of northern China. Utilizing native grasses for the restoration of degraded grasslands is an effective technological approach. is a superior indigenous grass species for grassland ecological restoration in northern China.
View Article and Find Full Text PDFTemperature-Related Bioclimatic Variables Play a Greater Role in the Spatial Distribution of Bumblebee Species in Northern Pakistan.
Insects
December 2024
College of Biological Resource and Food Engineering, Qujing Normal University, Qujing 655011, China.
Bumblebee species are vital wild pollinators, providing essential pollination services for various crops, fruits, and vegetables. However, their biodiversity is vulnerable to decline due to climate change, particularly in regions like northern Pakistan. Despite this, no research has yet been conducted on the distribution patterns of bumblebee species in this region.
View Article and Find Full Text PDFDaily activity patterns of a near-threatened endemic wetland specialist, the Southern African vlei rat (Otomys auratus).
Physiol Behav
January 2025
Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa; Mammal Research Institute, University of Pretoria, Hatfield, 0083, South Africa. Electronic address:
The genus Otomys exhibits diverse activity patterns in the field, making them ideal subjects for studying circadian biology. The Southern African vlei rat (Otomys auratus) has previously been categorised as diurnal or crepuscular, but also displays some nocturnal activity. This study aimed to confirm the temporal niche of vlei rats in a laboratory setting and examine changes in activity when provided with a running wheel.
View Article and Find Full Text PDFAdverse childhood experiences and diurnal cortisol pattern and heart rate variability in adults.
Psychoneuroendocrinology
January 2025
School of Sport, Exercise and Health Sciences, Loughborough University, United Kingdom.
Dysregulation of hypothalamic-pituitary-adrenal axis (HPA axis) and of the autonomic nervous system may link stress throughout the life course with poorer health. This study aims to investigate whether multiple adverse childhood experiences have a long-term impact on markers of these systems - cortisol secretion and heart rate variability - in adulthood. Data were from the Whitehall II cohort study.
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