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Endovascular intravascular intervention for central venous stenosis in maintenance hemodialysis patients: a retrospective observational study.
Front Cardiovasc Med
December 2024
Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Background: The number of people undergoing maintenance hemodialysis is increasing rapidly worldwide. Central vein stenosis (CVS) is a common vascular complication in undergoing hemodialysis, especially those with a history of catheterization. This study aimed to investigate the characteristics of CVS and the clinical effectiveness of percutaneous transluminal angioplasty (PTA) alone and sequential percutaneous transluminal stenting (PTS) in hemodialysis patients with CVS.
View Article and Find Full Text PDFReversal of Atherosclerotic Plaque Growth and Vulnerability: Effects of Lipid-Modifying and Anti-Inflammatory Therapeutic Agents.
Biomedicines
October 2024
Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Article Synopsis
- * Effective lipid-lowering therapies, like statins and PCSK9 inhibitors, have been shown to improve clinical outcomes by reducing plaque volume and enhancing its stability.
- * There's a growing need for new treatments that not only lower lipid levels but also target inflammation to stabilize vulnerable plaques and prevent adverse cardiac events.
Investigation of Chlorhexidine and Chitosan Gel-Based Coatings for the Prevention of Intravascular Catheter-Associated Infections Following Quality by Design Approach.
Biomedicines
September 2024
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, 6720 Szeged, Hungary.
Article Synopsis
- Intravascular catheter-associated infections are a serious health risk due to biofilm formation, necessitating effective and affordable solutions to enhance patient safety.
- The study developed an antimicrobial polymeric gel coating using chitosan and chlorhexidine on urinary catheters, using a quality-focused approach to optimize coating application.
- In vitro tests showed that the coating effectively released chlorhexidine and adhered well to the catheter, highlighting its potential to improve catheter safety and reduce infection risks.
Confocal microscopic oxygen imaging of xenograft tumors using Ir(III) complexes as in vivo intravascular and intracellular probes.
Sci Rep
August 2024
Molecular Pharmacology and Oncology, Graduate School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Hypoxia is an important feature of the tumor microenvironment (TME) of most solid tumors, and it is closely linked to cancer cell proliferation, therapy resistance, and the tumor immune response. Herein, we describe a method for hypoxia-induced heterogeneous oxygen distribution in xenograft tumors based on phosphorescence imaging microscopy (PLIM) using intravascular and intracellular oxygen probes. We synthesized Ir(III) complexes with polyethylene glycol (PEG) units of different molecular weights into the ligand as intravascular oxygen probes, BTP-PEGm (m = 2000, 5000, 10000, 20000).
View Article and Find Full Text PDFBoth Classical and Non-Classical Monocytes Patrol Glomerular Capillaries and Promote Acute Glomerular Inflammation.
Am J Pathol
January 2025
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. Electronic address:
Monocyte patrolling of the vasculature has been ascribed primarily to the non-classical monocyte subset. However, a recent study of the glomerular microvasculature provided evidence that both classical and non-classical monocytes undergo periods of intravascular retention and migration. Despite this, whether these subsets contribute differentially to acute glomerular inflammation is unknown.
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