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Concomitant virus infection increases mortality and worsens outcome of acute pancreatitis: A systematic review and meta-analysis.
Pancreatology
December 2024
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary. Electronic address:
Background: Acute pancreatitis (AP) is a major health threat, with a high mortality rate in severe forms. Though alcohol and bile-induced factors are the most common causes, increasing evidence suggests that viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human immunodeficiency virus (HIV) may also trigger AP development. Our study aims to explore this association in greater detail.
View Article and Find Full Text PDFMUC17 Is a Potential New Prognostic Biomarker and Promotes Pancreatic Cancer Progression in Obstructive Jaundice.
Oncology
October 2024
Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Article Synopsis
- The study investigates the role of MUC17 in pancreatic cancer (PC) progression, particularly under the influence of bile acids (BAs) and human serum from patients with pancreatic ductal adenocarcinoma (PDAC) and obstructive jaundice (OJ).
- Researchers found that higher levels of MUC17 are linked with poorer survival outcomes in PDAC patients, with significantly reduced survival time associated with elevated MUC17 expression.
- In laboratory tests, BAs and human serum treatment increased MUC17 levels and cell proliferation in PDAC cells, while reducing MUC17 led to decreased carcinogenic processes, highlighting MUC17 as a potential new biomarker for prognosis in PC.
Pancreatobiliary reflux increases macrophage-secreted IL-8 and activates the PI3K/NFκB pathway to promote cholangiocarcinoma progression.
Transl Oncol
July 2024
Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao 266003, China; Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:
Background: Persistent pancreaticobiliary reflux (PBR) is associated with a high risk of biliary malignancy. This study aimed to evaluate the proportion of PBR in biliary tract diseases and mechanisms by which PBR promoted cholangiocarcinoma progression.
Methods: Overall 227 consecutive patients with primary biliary tract disease participated in this study.
Function of mast cell and bile-cholangiocarcinoma interplay in cholangiocarcinoma microenvironment.
Gut
July 2024
Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Objective: The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign and malignant bile ducts and elucidate the generation, function and degradation of bile metabolites.
Design: Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics.
Late onset of biliopleural fistula following percutaneous transhepatic biliary drainage: a case report.
Biomedicine (Taipei)
March 2018
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Biliopleural fistula (BF) and formation of biliopleural effusion is a rare complication following percutaneous transhepatic biliary drainage (PTBD). It occurs when the pleura is traversed by the catheter before entering the bile duct. Biliopleural fistula should be suspected when right side pleural effusion develops following the PTBD procedure.
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