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Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Non-small cell lung cancer (NSCLC) is a widespread highly malignant type of lung cancer. Conventional chemotherapeutic drugs may be accompanied by both drug resistance and serious side effects in patients. Therefore, safer and more effective medications are urgently needed for the treatment of NSCLC.
View Article and Find Full Text PDFGlobal Research Hotspots and Trends in Advances of the Ilizarov Technique: A Bibliometric Mapping.
Orthop Surg
January 2025
Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.
Objective: An updated bibliometric analysis is needed to address the lack of comprehensive understanding of Ilizarov technique's research trends and hotspots, fostering collaboration and technology adoption. CiteSpace was utilized to perform co-citation analyzes on authors, countries, institutions, journals and cited journals, authors and cited literature, along with keywords. This approach aimed to identify leaders, collaborating institutions, and research hotspots associated with the Ilizarov technique, while also predicting future development trends.
View Article and Find Full Text PDFOptimizing multiprocessor performance in real-time systems using an innovative genetic algorithm approach.
Sci Rep
January 2025
Nanoelectronics Integrated Systems Center (NISC), Nile University, Giza, 12677, Egypt.
Due to its enormous influence on system functionality, researchers are presently looking into the issue of task scheduling on multiprocessors. Establishing the most advantageous schedules is often regarded as a difficult-to-compute issue. Genetic Algorithm is a recent tool employed by researchers to optimize scheduling tasks and boost performance, although this field of research is yet mostly unexplored.
View Article and Find Full Text PDFDevelopment of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity.
Int J Biol Macromol
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address:
This study presents the design, synthesis, and evaluation of a novel series of coumarin-based compounds (9a-t) as potential anticancer agents. The compounds were strategically designed to inhibit cancer-related carbonic anhydrase (CA) isoforms IX and XII and tubulin polymerization. Two approaches were employed for CA inhibition: utilizing the coumarin motif to occlude the CA active site entrance and incorporating zinc-binding groups (sulfonamide, carboxylic acid, and thiol) to interact with the catalytic zinc ion.
View Article and Find Full Text PDFSustainable utilization of bovine adipose tissue derivatives as robust antimicrobial agents against Methicillin-resistant Staphylococcus aureus.
BMC Microbiol
January 2025
Department of Internal Medicine and Infectious Diseases (Infectious Diseases), Faulty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: The excessive use of antibiotics is a major contributor to the global issue of antimicrobial resistance (AMR), a significant threat to human and animal health. Hence, assessing new strategies for managing Multi-Drug Resistant (MDR) microorganisms is vital. In this study, the use of mechanically isolated mature adipose cells (MIMACs) and their lysate (Adipolysate) as a new sustainable antimicrobial agent was assessed against Methicillin-resistant Staphylococcus aureus (MRSA).
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