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Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
JAMA Netw Open
January 2025
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Importance: The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation-associated ischemic stroke is unclear.
Objective: To investigate whether early DOAC treatment is associated with a net clinical benefit (NCB).
Design, Setting, And Participants: This was a post hoc analysis of the Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized clinical trial conducted across 103 sites in 15 countries in Europe, the Middle East, and Asia between November 6, 2017, and September 12, 2022, with a 90-day follow-up.
Mouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis.
Bio Protoc
January 2025
Department of Stomatology, Peking Union Medical College Hospital, Beijing, China.
Pulpitis is an important and prevalent disease within the oral cavity. Thus, animal models are necessary tools for basic research focused on pulpitis. Researchers worldwide often use dogs and miniature pigs to construct animal models of pulpitis.
View Article and Find Full Text PDFStatoliths function in gravity perception in plants: yes, no, yes!
Planta
January 2025
Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, FL, 32901, USA.
The starch-statolith theory was established science for a century when the existence of gravitropic, starchless mutants questioned its premise. However, detailed kinetic studies support a statolith-based mechanism for graviperception. Gravitropism is the directed growth of plants in response to gravity, and the starch-statolith hypothesis has had a consensus among scientists as the accepted model for gravity perception.
View Article and Find Full Text PDFFemoral hydatid cyst: A rare localization of bone echinococcosis: A case report.
Radiol Case Rep
March 2025
Department of Radiology, Mohammed VI University Hospital, Faculty of Medicine, University Mohammed First, Oujda, Morocco.
Echinococcosis, or hydatid disease, is an endemic disease that affects many regions worldwide and remains a significant public health issue in areas with high endemicity. It is caused by an infection with the dog tapeworm *Echinococcus granulosus*, which is transmitted to humans either through direct contact with dogs or by ingesting contaminated food. This disease primarily affects internal organs, particularly the liver and lungs.
View Article and Find Full Text PDFTransposition of great arteries (TGA) is a critical congenital heart disease leading to a fatal outcome if timely management is not provided. Management in low-income countries is challenging. A retrospective analysis was carried out at Sudan Heart Center for infants with TGA who underwent balloon atrial septostomy (BAS) from January 2010 to December 2020.
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