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Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation.
Elife
January 2025
Department of Cognitive Psychology, University of Hamburg, Hamburg, Germany.
When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood. Here, we show that noradrenergic stimulation after memory retrieval impairs subsequent remembering, depending on hippocampal and cortical signals emerging during retrieval.
View Article and Find Full Text PDFCircadian influences on sudden cardiac death and cardiac electrophysiology.
J Mol Cell Cardiol
January 2025
Department of Physiology, University of Kentucky, Lexington, KY, USA; Department of Internal Medicine, University of Kentucky, Lexington, KY, USA. Electronic address:
Cardiologists have analyzed daily patterns in the incidence of sudden cardiac death to identify environmental, behavioral, and physiological factors that trigger fatal arrhythmias. Recent studies have indicated an overall increase in sudden cardiac arrest during daytime hours when the frequency of arrhythmogenic triggers is highest. The risk of fatal arrhythmias arises from the interaction between these triggers-such as elevated sympathetic signaling, catecholamine levels, heart rate, afterload, and platelet aggregation-and the heart's susceptibility (myocardial substrate) to them.
View Article and Find Full Text PDFBehavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism.
J Integr Neurosci
January 2025
Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China.
Background: Recent studies suggest that the anterior limb of the internal capsule may be an area of convergence for multiple compulsion loops. In this study, the role of different dopaminergic compulsion loops in the mechanism of obsessive-compulsive disorder (OCD) was investigated by selectively damaging dopaminergic neurons or fibers in the corresponding targets with 6-hydroxydopamine (6-OHDA) and depicting the anatomical map of various compulsion loops located in the anterior limb of the internal capsule.
Methods: A total of 52 male Sprague Dawley (SD) rats were exposed to either saline (1 mL/kg, NS group, n = 6) or quinpirole (QNP, dopamine D2-agonist, 0.
HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE.
Georgian Med News
November 2024
2Department of Chemistry, College of Science, University of Mosul, Iraq.
Parkinson's disease (PD) is a complicated neurodegenerative disease that is the most prevalent severe movement disorder worldwide. The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine γ-lyase (CSE) with some biochemical parameters in the serum of patients with PD in Mosul City (Iraq), which include Serotonin (SERT), dopamine (DA), sphingomyelin (SM), vitamin B12, Acetylcholine esterase (AChE), monoamine oxidase (MAO), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT). Samples reached (100), which included: (40) for the Parkinson's patients group, and (60) for the control group.
View Article and Find Full Text PDFA Novel Rat Model for Inflammatory Gut-Brain Interactions in Parkinson's Disease.
Eur J Neurosci
January 2025
Department of Anatomy, Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Gut inflammation is a salient prodromal feature of Parkinson's disease (PD) implicated in pathologic processes leading to nigrostriatal dopaminergic degeneration. However, existing rodent models of PD are suboptimal for investigating the interaction between gut inflammation and neuropathology. This study aimed to develop a rat model of PD in which gut inflammation exacerbated PD symptoms induced by a parkinsonian lesion.
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