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[Two years' experience with levodopa-entacapone-carbidopa intestinal gel treatment in advanced Parkinson's disease].
Orv Hetil
January 2025
1 Universitatea de Medicină, Farmacie, Științe și Tehnologie "George Emil Palade" din Târgu Mures (Marosvásárhelyi George Emil Palade Orvosi, Gyógyszerészeti, Tudomány és Technológiai Egyetem) Marosvásárhely, Gral Ion Dumitrache u. 20/A, 540081 Romania.
The Relationship Between Oxidative Stress and Infertility Due to Antihypertensive Drugs in Rattus Norvegicus.
Animals (Basel)
December 2024
Department of Obstetrics and Gynecology, Ankara University, Ankara 06100, Turkey.
This study aimed to investigate the effect of antihypertensive drugs on reproductive function in Rattus norvegicus and demonstrate the potential role of oxidative stress in reproductive dysfunction. Rattus norvegicus were selected as the experimental animals and divided into the following groups: healthy (control group), clonidine (CL), rilmenidine (RLD), methyldopa (MTL), amlodipine (ALD), and ramipril (RML). Each individual in each group was marked from one to six.
View Article and Find Full Text PDFHow well is the female population represented in clinical trials with infusion therapies for Parkinson's disease? A systematic review and metanalysis.
Eur J Neurol
January 2025
Parkinson and Movement Disorders Unit, Study Center for Neurodegenerative diseases (CESNE), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Background: Parkinson's disease (PD) is a neurodegenerative disorder affecting both sexes, but differences exist between male and female in clinical manifestations, functional impact of symptoms and hormonal influences. Therefore, representativeness of females in PD trials indirectly determines the external validity of the clinical research in this field.
Objective: To estimate the representativeness of female in infusion therapy trials for advanced PD.
Different patterns of acute saccadic response to levodopa in de novo Parkinson's disease.
J Neurol
December 2024
Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
Background: L-dopa (LD) effects on visually guided saccades (VGS) have been poorly investigated in de novo Parkinson's disease (PD) patients through a standardized acute challenge test.
Objectives: To assess the acute saccadic effects of LD as well as possible different patterns of VGS response to LD in a consistent population of de novo PD.
Methods: VGS were assessed among de novo PD at baseline and 2 h after the administration of LD/carbidopa 250/25 mg.
Biomimetic Approach for Optimal Designing of the Shape and Controlled Release of Therapeutics from Tricompartmental Microcarriers for Managing Parkinson's Disease.
ACS Appl Bio Mater
January 2025
Department of Materials Science and Engineering, Indian Institute of Technology Delhi, Hauz Khas, Delhi, India 110016.
Inspired by the intricate cellular morphology and the discoid shape of red blood cells (RBCs), biomimetic tricompartmental microcarriers (TCM) with controlled release profiles were engineered using an electrohydrodynamic--jetting technique for efficient management of Parkinson's disease (PD). While jetting, Levodopa (LD), CD (Carbidopa), and ENT (Entacapone) (3 PD drugs) were directly encapsulated in the three individual compartments of the TCM used for oral administration. The optimal shape and controlled release profiles were obtained by employing the Taguchi orthogonal L9 design-of-experiment approach by systematically varying the processing parameters, i.
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