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New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining.
Antibiotics (Basel)
March 2022
School of Biomolecular and Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.
Glycosylated polyene macrolides include effective antifungal agents, such as pimaricin, nystatin, candicidin, and amphotericin B. For the treatment of systemic mycoses, amphotericin B has been described as a gold-standard antibiotic because of its potent activity against a broad spectrum of fungal pathogens, which do not readily become resistant. However, amphotericin B has severe toxic side effects, and the development of safer alternatives remains an important objective.
View Article and Find Full Text PDFGenome Mining and Metabolic Profiling Uncover Polycyclic Tetramate Macrolactams from SCSIO 5802.
Mar Drugs
July 2021
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
We have previously shown deep-sea-derived SCSIO 5802 to produce two types of active secondary metabolites, abyssomicins and candicidins. Here, we report the complete genome sequence of SCSIO 5802 employing bioinformatics to highlight its potential to produce at least 21 categories of natural products. In order to mine novel natural products, the production of two polycyclic tetramate macrolactams (PTMs), the known 10--HSAF () and a new compound, koyanamide A (), was stimulated via inactivation of the abyssomicin and candicidin biosynthetic machineries.
View Article and Find Full Text PDFCandicidin Isomer Production Is Essential for Biocontrol of Cucumber Rot by Streptomyces albidoflavus W68.
Appl Environ Microbiol
April 2021
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Diseases caused by soilborne fungal pathogens result in significant crop yield losses and quality reduction. strain W68 is effective in controlling several soilborne fungal diseases. To identify antifungal substances critical for biocontrol activity of W68, the genome of W68 was sequenced and a linear chromosome of 6.
View Article and Find Full Text PDFCoordinate Regulation of Antimycin and Candicidin Biosynthesis.
mSphere
December 2016
School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.
species produce an incredible array of high-value specialty chemicals and medicinal therapeutics. A single species typically harbors ~30 biosynthetic pathways, but only a few them are expressed in the laboratory; thus, poor understanding of how natural-product biosynthesis is regulated is a major bottleneck in drug discovery. Antimycins are a large family of anticancer compounds widely produced by species, and their regulation is atypical compared to that of most other natural products.
View Article and Find Full Text PDFDevelopment of sp. FR-008 as an emerging chassis.
Synth Syst Biotechnol
September 2016
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
Microbial-derived natural products are important in both the pharmaceutical industry and academic research. As the metabolic potential of original producer especially is often limited by slow growth rate, complicated cultivation profile, and unfeasible genetic manipulation, so exploring a as a super industrial chassis is valuable and urgent. sp.
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