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Healthcare (Basel)
December 2024
Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8509, Japan.
This study aimed to determine the association between chronic schizophrenia, extrapyramidal symptoms (EPSs), body composition, nutritional status, and dynapenia/sarcopenia. Data from 68 chronic patients with schizophrenia were analyzed using Spearman's rho correlation coefficients, Kruskal-Wallis test, Mann-Whitney U test, and Cramér's V statistics. Among the participants, 32.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Department of Pharmacy, University of Split School of Medicine, Soltanska 2A, 21000 Split, Croatia.
Background/objectives: Schizophrenia is a chronic psychiatric disorder usually managed with antipsychotics, which can cause adverse drug reactions (ADRs) that may impact patients' attitudes toward their treatment, as well as treatment adherence. This study aimed to assess the influence of ADRs and other factors on treatment attitudes among female patients with schizophrenia.
Methods: A cross-sectional study was conducted at the Vrapče Psychiatry Clinic with 109 female schizophrenia patients.
Int J Neuropsychopharmacol
December 2024
Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Negative symptoms of schizophrenia represent an unmet therapeutic need for many patients on whom pentoxifylline may be effective in terms of its dopaminergic, anti-inflammatory, and cerebral blood flow-increasing properties. This study aimed to evaluate pentoxifylline as a therapeutic agent for improving negative symptoms of schizophrenia.
Methods: Chronic schizophrenia outpatients experiencing significant negative symptoms were randomly allocated to receive pentoxifylline 400 mg or matched placebo q12hr for eight weeks.
Int Clin Psychopharmacol
December 2024
Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences.
Current treatments for schizophrenia encounter resistance, limited efficacy, and limiting complications, necessitating novel approaches. The effects of saffron on negative symptoms were investigated as it has shown neuroprotective and antipsychotic properties. Fifty-six clinically stable chronic schizophrenic outpatients were equally assigned to saffron 15 mg q12hr or placebo groups while continuing risperidone.
View Article and Find Full Text PDFCureus
December 2024
Gastroenterology and Hepatology, Surrey and Sussex Healthcare NHS Trust, Redhill, GBR.
Patients with chronic liver disease (CLD) are prone to complications associated with impaired liver functioning. This coupled with iron-deficiency anaemia (IDA) can predispose them to multiple comorbidities. We present an interesting case of a 69-year-old woman with a background history of liver cirrhosis due to metabolic dysfunction-associated steatotic liver disease (MASLD) with frequent travels to Bangladesh, a southeast Asian country known for having high levels of manganese (Mn) in water for domestic use.
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